Tchem NOX5 NADPH oxidase 5

Protein Summary

Description

Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q96PH1
• B2RBJ4
• Q08AN2
• Q08AN3
• Q8TEQ1
• Q8TER4
• Q96PH2
• Q96PJ8
• Q96PJ9
• Q9H6E0
• Q9HAM8

Gene Name

• NOX5

Ensembl ID

• ENST00000260364
• ENSP00000454143
• ENSG00000255346
• ENST00000388866
• ENSP00000373518
• ENST00000448182
• ENSP00000410887
• ENST00000455873
• ENSP00000416828
• ENST00000530406
• ENSP00000432440

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.97
cell type or tissue	0.78
tissue	0.73
kinase	0.58

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Nadph Oxidase 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.64   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 223   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.64   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0