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Tbio
NOX3
NADPH oxidase 3

Protein Summary
Description
NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000159060
  • ENSP00000159060
  • ENSG00000074771

Symbol
  • MOX2
  • MOX-2
  • GP91-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
virus perturbation
0.83
trait
0.61
tissue
0.58
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.39   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.39   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
CYBA
Tbio
Novelty:  0.00177762
Score:  0.989
Data Source:  Reactome,STRINGDB
NOXA1
Tbio
Family:  Enzyme
Novelty:  0.03052419
Score:  0.98
Data Source:  Reactome,STRINGDB
NCF1
Tbio
Novelty:  0.00120288
Score:  0.978
Data Source:  Reactome,STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.978
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.924
Data Source:  Reactome,STRINGDB
NOXO1
Tbio
Family:  Enzyme
Novelty:  0.02648748
Score:  0.869
Data Source:  STRINGDB
NCF4
Tbio
Novelty:  0.00560244
Score:  0.811
Data Source:  STRINGDB
DECR1
Tbio
Family:  Enzyme
Novelty:  0.02699187
Score:  0.739
Data Source:  STRINGDB
OTOP1
Tbio
Novelty:  0.04916753
Score:  0.694
Data Source:  STRINGDB
PHTF1
Tdark
Novelty:  0.05632054
Score:  0.659
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (89)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate NADPH Oxidases
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate NADPH Oxidases
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
1
2
10.4
self reported educational attainment
1
1
1
10.1
cognitive function measurement
1
1
1
7.9
diet measurement
2
1
2
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
10.4
self reported educational attainment
1
10.1
cognitive function measurement
1
7.9
diet measurement
2
4.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADPH oxidase 3
VGNC:3596
472169
Macaque
NADPH oxidase 3
701576
Mouse
MGI:2681162
224480
Rat
RGD:1303190
292279
Dog
NADPH oxidase 3
VGNC:43904
484046
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADPH oxidase 3
Macaque
NADPH oxidase 3
Mouse
Rat
Dog
NADPH oxidase 3
Publication Statistics
PubMed Score 58.39
PubMed score by year
PubTator Score 27.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title