Protein Summary
NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. This gene encodes a member of the NOX family of NADPH oxidases. These enzymes have the capacity to generate superoxide and other reactive oxygen species (ROS) and transport electrons across the plasma membrane. The ROS generated by family members have been implicated in numerous biological functions including host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. The protein encoded by this gene is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.[provided by RefSeq, May 2009]
- ENST00000159060
- ENSP00000159060
- ENSG00000074771
- MOX2
- MOX-2
- GP91-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.92 | ||
virus perturbation | 0.83 | ||
trait | 0.61 | ||
tissue | 0.58 | ||
cell line | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.39 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 191 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 58.39 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 191 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (41)
Nearest Tclin Targets
Pathways (89)
Reactome (4)
WikiPathways (85)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate NADPH Oxidases | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Rho GTPases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
RHO GTPase Effectors | ||||
RHO GTPases Activate NADPH Oxidases | ||||
Signal Transduction | ||||
Signaling by Rho GTPases | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 1 | 2 | 10.4 | |||||
self reported educational attainment | 1 | 1 | 1 | 10.1 | |||||
cognitive function measurement | 1 | 1 | 1 | 7.9 | |||||
diet measurement | 2 | 1 | 2 | 4.6 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 2 | 10.4 | |||||
self reported educational attainment | 1 | 10.1 | |||||
cognitive function measurement | 1 | 7.9 | |||||
diet measurement | 2 | 4.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NADPH oxidase 3 | VGNC:3596 | 472169 | |||||
Macaque | NADPH oxidase 3 | 701576 | ||||||
Mouse | MGI:2681162 | 224480 | ||||||
Rat | RGD:1303190 | 292279 | ||||||
Dog | NADPH oxidase 3 | VGNC:43904 | 484046 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NADPH oxidase 3 | |||||
Macaque | NADPH oxidase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NADPH oxidase 3 | |||||
Publication Statistics
PubMed Score 58.39
PubMed score by year
PubTator Score 27.71
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (15)
Items per page:
0 of 0
PMID | Year | Title |
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