Protein Summary
NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
- ENST00000217885
- ENSP00000217885
- ENSG00000007952
- ENST00000372966
- ENSP00000362057
- MOX1
- NOH1
- MOX1
- NOH1
- NOH-1
- GP91-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
biological process | 0.97 | ||
biological term | 0.94 | ||
protein domain | 0.92 | ||
virus perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 699.28 (req: < 5)
Gene RIFs: 190 (req: <= 3)
Antibodies: 324 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 699.28 (req: >= 5)
Gene RIFs: 190 (req: > 3)
Antibodies: 324 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 61
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0