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Tchem
NOTCH4
Neurogenic locus notch homolog protein 4

Protein Summary
Description
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375023
  • ENSP00000364163
  • ENSG00000204301
  • ENST00000425600
  • ENSP00000401321
  • ENSG00000238196
  • ENST00000439349
  • ENSP00000408335
  • ENSG00000223355
  • ENST00000457094
  • ENSP00000403447
  • ENSG00000234876

Symbol
  • INT3
  • INT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
cellular component
0.91
PubMedID
0.87
disease
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.58   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.58   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0