NOTCH4
Neurogenic locus notch homolog protein 4
Protein Summary
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity). This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognat ...more
- ENST00000375023
- ENSP00000364163
- ENSG00000204301
- ENST00000425600
- ENSP00000401321
- ENSG00000238196
- ENST00000439349
- ENSP00000408335
- ENSG00000223355
- ENST00000457094
- ENSP00000403447
- ENSG00000234876
- INT3
- INT3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
trait | 1 | ||
cellular component | 0.91 | ||
PubMedID | 0.87 | ||
disease | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.81 (req: < 5)
Gene RIFs: 104 (req: <= 3)
Antibodies: 303 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 208.81 (req: >= 5)
Gene RIFs: 104 (req: > 3)
Antibodies: 303 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (185)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (46)
Reactome (18)
KEGG (7)
PathwayCommons (13)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective LFNG causes SCDO3 | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective LFNG causes SCDO3 | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (3)
Components (9)
Processes (16)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (316)
Items per page:
1 – 5 of 316
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
complement C4 measurement | 2 | 4 | 7 | 97.4 | ||||||
1 | 3 | 0 | 2.6 | 96.9 | ||||||
Items per page:
1 – 5 of 316
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
complement C4 measurement | 7 | 97.4 | |||||
complement C4 measurement | 7 | 97.4 | |||||
complement C4 measurement | 7 | 97.4 | |||||
complement C4 measurement | 7 | 97.4 | |||||
0 | 2.6 | 96.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:107471 | 18132 | ||||||
Rat | RGD:1303282 | 406162 | ||||||
Dog | notch 4 | VGNC:43900 | 481726 | |||||
Horse | notch 4 | VGNC:20819 | 100059541 | |||||
Cow | notch 4 | VGNC:32179 | 536128 | |||||
Publication Statistics
PubMed Score 208.81
PubMed score by year
PubTator Score 188.65
PubTator score by year
Related Publications
Text Mined References (157)
GeneRif Annotations (104)
Items per page:
0 of 0
PMID | Year | Title |
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