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Tchem
NOTCH1
Neurogenic locus notch homolog protein 1

Protein Summary
Description
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4(+) and CD8(+) cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or diff ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277541
  • ENSP00000277541
  • ENSG00000148400

Symbol
  • TAN1
  • hN1
  • AOS5
  • TAN1
  • AOVD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
1
protein domain
1
PubMedID
0.98
molecular function
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9562.48   (req: < 5)
Gene RIFs: 1102   (req: <= 3)
Antibodies: 1214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9562.48   (req: >= 5)
Gene RIFs: 1102   (req: > 3)
Antibodies: 1214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 154
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 97
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0