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Tbio
NOP58
Nucleolar protein 58

Protein Summary
Description
Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. The protein encoded by this gene is a core component of box C/D small nucleolar ribonucleoproteins. Some box C/D small nucleolar RNAs (snoRNAs), such as U3, U8, and U14, are dependent upon the encoded protein for their synthesis. This protein is SUMOylated, which is necessary for high affinity binding to snoRNAs. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264279
  • ENSP00000264279
  • ENSG00000055044

Symbol
  • NOL5
  • NOP5
  • NOP5
  • HSPC120
  • NOP5/NOP58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.94
interacting protein
0.93
small molecule perturbation
0.88
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.07   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.07   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (489)
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.962984984
p_ni:  0.037015016
Score:  0.999
Data Source:  BioPlex,STRINGDB
NEMP1
Tdark
Novelty:  0.37603456
p_int:  0.775533154
p_ni:  0.224466846
Score:  0.195
Data Source:  BioPlex,STRINGDB
WDR43
Tbio
Novelty:  0.12680949
Score:  0.999
Data Source:  STRINGDB
BOP1
Tbio
Novelty:  0.03512044
Score:  0.999
Data Source:  STRINGDB
TBL3
Tdark
Novelty:  0.05195885
Score:  0.999
Data Source:  STRINGDB
NOP56
Tbio
Novelty:  0.01256937
Score:  0.999
Data Source:  STRINGDB
DKC1
Tbio
Novelty:  0.00352181
Score:  0.999
Data Source:  STRINGDB
BMS1
Tbio
Novelty:  0.0349992
Score:  0.999
Data Source:  STRINGDB
NOC4L
Tdark
Novelty:  0.39929311
Score:  0.999
Data Source:  STRINGDB
KRR1
Tbio
Novelty:  0.07965454
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
2
2
74.7
alkaline phosphatase measurement
1
1
1
61
triglyceride measurement
1
1
1
31.4
apolipoprotein B measurement
1
1
1
27.2
low density lipoprotein cholesterol measurement
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
74.7
alkaline phosphatase measurement
1
61
triglyceride measurement
1
31.4
apolipoprotein B measurement
1
27.2
low density lipoprotein cholesterol measurement
1
21.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOP58 ribonucleoprotein
VGNC:2715
459883
Macaque
NOP58 ribonucleoprotein
703859
Mouse
MGI:1933184
55989
Rat
RGD:620484
60373
Dog
NOP58 ribonucleoprotein
VGNC:43892
100856234
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOP58 ribonucleoprotein
Macaque
NOP58 ribonucleoprotein
Mouse
Rat
Dog
NOP58 ribonucleoprotein
Publication Statistics
PubMed Score 47.07
PubMed score by year
PubTator Score 17.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title