Tbio NOP56 Nucleolar protein 56

Protein Summary

Description

Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs. Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• O00567
• Q2M3T6
• Q9NQ05

Gene Name

• NOP56

Ensembl ID

• ENST00000329276
• ENSP00000370589
• ENSG00000101361

Symbol

• NOL5A
• NOL5A
• SCA36

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
interacting protein	1
hub protein	0.97
kinase perturbation	0.96
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Nucleolar Protein 56

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribonucleoprotein / Nucleolar Protein 56

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.18   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.18   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (568)

Explore Interacting Targets

1 – 10 of 568

• See Interactions on String-DB

NOLC1

Tbio

Novelty:  0.01922261

p_int:  0.99603831

p_ni:  0.00396169

Score:  0.997

Data Source:  BioPlex,STRINGDB

FBL

Tbio

Family:  Enzyme

Novelty:  0.00080634

p_int:  0.987905385

p_ni:  0.012094615

Score:  0.999

Data Source:  BioPlex,STRINGDB

KPNA6

Tbio

Novelty:  0.03516499

p_int:  0.942424639

p_ni:  0.057575361

Score:  0.529

Data Source:  BioPlex,STRINGDB

KPNA1

Tbio

Novelty:  0.00863582

p_int:  0.928749298

p_ni:  0.071250702

Score:  0.524

Data Source:  BioPlex,STRINGDB

EIF3J

Tbio

Novelty:  0.04648652

p_int:  0.91964792

p_ni:  0.077901905

p_wrong:  0.002450175

Data Source:  BioPlex

GPATCH4

Tdark

Novelty:  1.13040547

p_int:  0.904405661

p_ni:  0.095594339

Score:  0.477

Data Source:  BioPlex,STRINGDB

RPL18

Tbio

Novelty:  0.01765545

p_int:  0.894323298

p_ni:  0.105676702

Score:  0.571

Data Source:  BioPlex,STRINGDB

RBM4

Tbio

Novelty:  0.02034191

p_int:  0.887900082

p_ni:  0.112099918

Score:  0.15

Data Source:  BioPlex,STRINGDB

KPNA5

Tbio

Novelty:  0.0762372

p_int:  0.884707944

p_ni:  0.115292056

Score:  0.218

Data Source:  BioPlex,STRINGDB

NEUROG3

Tbio

Family:  TF

Novelty:  0.00341077

p_int:  0.873683194

p_ni:  0.126316805

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (9)

KEGG (1)

Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

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1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (4)

Components (9)

Processes (1)

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Items per page:

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1 – 4 of 4

GO Term	Evidence	Assigned by
snoRNA binding	Inferred from Direct Assay (IDA)	BHF-UCL
histone methyltransferase binding	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Isopeptide bond
Methylation
Neurodegeneration
Nucleus
Phosphoprotein
Polymorphism

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NOP56 ribonucleoprotein	VGNC:6216	458047
Macaque	NOP56 ribonucleoprotein		718202
Mouse	NOP56 ribonucleoprotein	MGI:1914384	67134
Rat	NOP56 ribonucleoprotein	RGD:1308892	362214
Dog	NOP56 ribonucleoprotein	VGNC:43891	612871

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NOP56 ribonucleoprotein
Macaque	NOP56 ribonucleoprotein
Mouse	NOP56 ribonucleoprotein
Rat	NOP56 ribonucleoprotein
Dog	NOP56 ribonucleoprotein

Publication Statistics

PubMed Score 78.18

PubMed score by year

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PubTator Score 28.40

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Related Publications

Text Mined References (32)

GeneRif Annotations (8)

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10

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PMID	Year	Title