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Tbio
NOP53
Ribosome biogenesis protein NOP53

Protein Summary
Description
Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis (PubMed:24120868). In ribosome biogenesis, may also play a role in rRNA transcription (PubMed:27729611). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions (PubMed:21741933, PubMed:24120868, PubMed:27829214). DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and allow p53/TP53 activation (PubMed:24120868, PubMed:27829214). It may also positively regulate the function of p53/TP53 in cell cycle arrest and apoptosis through direct interaction, preventing its MDM2-dependent ubiquitin-mediated proteasomal degradation (PubMed:22522597). Originally identified as a tumor suppressor, it may also play a role in cell proliferation and apopt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246802
  • ENSP00000246802
  • ENSG00000105373

Symbol
  • GLT
  • GLTSCR2
  • PICT1
  • PICT1
  • PICT-1
  • GLTSCR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.06   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.06   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (327)
OSBPL6
Tbio
Novelty:  0.25692861
p_int:  0.999999921
p_ni:  7.9e-8
Data Source:  BioPlex
OSBPL3
Tbio
Novelty:  0.06106368
p_int:  0.999998053
p_ni:  0.000001946
Data Source:  BioPlex
ZNF189
Tdark
Family:  TF
Novelty:  0.28362251
p_int:  0.993941964
p_ni:  0.006021696
p_wrong:  0.00003634
Data Source:  BioPlex
PABPC4L
Tdark
Novelty:  0.94386609
p_int:  0.992395197
p_ni:  0.005347093
p_wrong:  0.002257709
Score:  0.157
Data Source:  BioPlex,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.991239167
p_ni:  0.008760833
Data Source:  BioPlex
MKRN1
Tbio
Family:  Enzyme
Novelty:  0.04485183
p_int:  0.989073638
p_ni:  0.010436692
p_wrong:  0.00048967
Score:  0.159
Data Source:  BioPlex,STRINGDB
UPF1
Tbio
Novelty:  0.00311006
p_int:  0.979454985
p_ni:  0.020545015
Score:  0.165
Data Source:  BioPlex,STRINGDB
STAU2
Tbio
Novelty:  0.03802876
p_int:  0.97783966
p_ni:  0.02216034
Data Source:  BioPlex
PRR3
Tdark
Novelty:  0.71308048
p_int:  0.977599758
p_ni:  0.018371227
p_wrong:  0.004029014
Data Source:  BioPlex
ZC3HAV1
Tbio
Novelty:  0.01357759
p_int:  0.977164551
p_ni:  0.022835449
Score:  0.392
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
1
2
39.6
Age-related nuclear cataract
1
1
0
5.7
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
39.6
Age-related nuclear cataract
0
5.7
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOP53 ribosome biogenesis factor
VGNC:6629
107969775
Macaque
NOP53 ribosome biogenesis factor
717454
Mouse
MGI:2154441
68077
Rat
RGD:1303085
292624
Dog
NOP53 ribosome biogenesis factor
VGNC:43890
476424
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOP53 ribosome biogenesis factor
Macaque
NOP53 ribosome biogenesis factor
Mouse
Rat
Dog
NOP53 ribosome biogenesis factor
Publication Statistics
PubMed Score 304.06
PubMed score by year
PubTator Score 30.56
PubTator score by year
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Related Publications
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PMID
Year
Title