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Tbio
NOP14
Nucleolar protein 14

Protein Summary
Description
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity). This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314262
  • ENSP00000315674
  • ENSG00000087269
  • ENST00000398071
  • ENSP00000381146
  • ENST00000416614
  • ENSP00000405068

Symbol
  • C4orf9
  • NOL14
  • UTP2
  • NOL14
  • C4orf9
  • RES425
  • RES4-25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor binding site profile
0.91
interacting protein
0.75
transcription factor perturbation
0.74
cellular component
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (347)
BYSL
Tbio
Novelty:  0.01919968
p_int:  0.999993697
p_ni:  0.000006303
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.999946235
p_ni:  0.000053765
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999111068
p_ni:  0.000888932
Data Source:  BioPlex
SEC31A
Tbio
Novelty:  0.0350228
p_int:  0.998814873
p_ni:  0.001185127
Score:  0.202
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.99881338
p_ni:  0.00118662
Score:  0.204
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.996748254
p_ni:  0.003251746
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.988910373
p_ni:  0.011089626
p_wrong:  1e-9
Score:  0.981
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.97417181
p_ni:  0.02582819
Score:  0.522
Data Source:  BioPlex,STRINGDB
GPATCH4
Tdark
Novelty:  1.13040547
p_int:  0.959973453
p_ni:  0.040026547
Score:  0.566
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.958189304
p_ni:  0.041810696
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
69.2
self reported educational attainment
1
1
1
68.3
household income
2
6
6
64
cigarettes per day measurement
3
3
3
60.2
smoking initiation
2
1
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
69.2
self reported educational attainment
1
68.3
household income
6
64
cigarettes per day measurement
3
60.2
smoking initiation
2
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOP14 nucleolar protein
VGNC:650
471124
Macaque
NOP14 nucleolar protein
720068
Mouse
MGI:1922666
75416
Rat
RGD:1305605
289724
Dog
NOP14 nucleolar protein
VGNC:43887
479076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOP14 nucleolar protein
Macaque
NOP14 nucleolar protein
Mouse
Rat
Dog
NOP14 nucleolar protein
Publication Statistics
PubMed Score 14.61
PubMed score by year
PubTator Score 10.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title