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Tbio
NOP10
H/ACA ribonucleoprotein complex subunit 3

Protein Summary
Description
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nuc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328848
  • ENSP00000332198
  • ENSG00000182117

Symbol
  • NOLA3
  • DKCB1
  • NOLA3
  • NOP10P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.79
transcription factor binding site profile
0.75
gene perturbation
0.74
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.14   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.14   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (202)
DKC1
Tbio
Novelty:  0.00352181
p_int:  0.998206971
p_ni:  0.001792924
p_wrong:  1.05e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GAR1
Tbio
Novelty:  0.26091307
p_int:  0.993637832
p_ni:  0.006357665
p_wrong:  0.000004502
Score:  0.999
Data Source:  BioPlex,STRINGDB
BCHE
Tclin
Family:  Enzyme
Novelty:  0.00031267
p_int:  0.991709465
p_ni:  0.008290035
p_wrong:  5e-7
Score:  0.524
Data Source:  BioPlex,STRINGDB
WRAP53
Tbio
Family:  Enzyme
Novelty:  0.0204638
p_int:  0.95210417
p_ni:  0.0477793
p_wrong:  0.000116529
Score:  0.961
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.920847022
p_ni:  0.079152636
p_wrong:  3.42e-7
Score:  0.412
Data Source:  BioPlex,STRINGDB
RBM34
Tdark
Novelty:  0.58131282
p_int:  0.790702563
p_ni:  0.20480941
p_wrong:  0.004488027
Score:  0.272
Data Source:  BioPlex,STRINGDB
NHP2
Tbio
Novelty:  0.01414024
Score:  0.999
Data Source:  STRINGDB
SNU13
Tbio
Novelty:  0.01613497
Score:  0.996
Data Source:  STRINGDB
NOP56
Tbio
Novelty:  0.01256937
Score:  0.993
Data Source:  STRINGDB
NAF1
Tbio
Novelty:  2.99493689
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
43.2
mean platelet volume
1
1
1
38.8
refractive error
1
2
2
33.7
self reported educational attainment
2
1
2
20.4
schizophrenia
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
43.2
mean platelet volume
1
38.8
refractive error
2
33.7
self reported educational attainment
2
20.4
schizophrenia
1
12.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NOP10 ribonucleoprotein
VGNC:1907
746535
Mouse
MGI:1913431
66181
Dog
NOP10 ribonucleoprotein
VGNC:43886
607299
Horse
NOP10 ribonucleoprotein
VGNC:20805
100630310
Cow
NOP10 ribonucleoprotein
VGNC:32164
616675
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NOP10 ribonucleoprotein
Mouse
Dog
NOP10 ribonucleoprotein
Horse
NOP10 ribonucleoprotein
Cow
NOP10 ribonucleoprotein
Publication Statistics
PubMed Score 48.14
PubMed score by year
PubTator Score 17.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title