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Tbio
NOMO1
Nodal modulator 1

Protein Summary
Description
May antagonize Nodal signaling. This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287667
  • ENSP00000287667
  • ENSG00000103512
  • ENST00000619292
  • ENSP00000482008
  • ENSG00000274779

Symbol
  • PM5
  • PM5
  • Nomo
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.81
transcription factor perturbation
0.61
cell type or tissue
0.58
protein domain
0.58
cell line
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
NCLN
Tbio
Novelty:  0.10851333
p_int:  0.999916003
p_ni:  0.000083997
Score:  0.872
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.92498634
p_ni:  0.07501366
Data Source:  BioPlex
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
p_int:  0.912951951
p_ni:  0.087048049
Data Source:  BioPlex
TNFSF10
Tchem
Novelty:  0.00096612
p_int:  0.904816173
p_ni:  0.095183827
Data Source:  BioPlex
PSCA
Tbio
Novelty:  0.00323778
p_int:  0.845233132
p_ni:  0.154766868
Data Source:  BioPlex
MLC1
Tbio
Family:  IC
Novelty:  0.00957425
p_int:  0.84186806
p_ni:  0.15813194
Data Source:  BioPlex
IMPAD1
Tbio
Family:  Enzyme
Novelty:  0.08211251
p_int:  0.828523545
p_ni:  0.171476455
Data Source:  BioPlex
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.820933423
p_ni:  0.179066577
Data Source:  BioPlex
IL5RA
Tclin
Novelty:  0.01418963
p_int:  0.817810238
p_ni:  0.182189762
Data Source:  BioPlex
CD96
Tbio
Novelty:  0.02087722
p_int:  0.787025262
p_ni:  0.212974738
Score:  0.416
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cholesteryl ester 20:3 measurement
1
2
2
70.1
free cholesterol:total lipids ratio
2
2
2
65.6
high density lipoprotein cholesterol measurement
3
2
3
65.6
very low density lipoprotein cholesterol measurement
6
3
6
65.1
low density lipoprotein cholesterol measurement
3
3
3
54.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cholesteryl ester 20:3 measurement
2
70.1
free cholesterol:total lipids ratio
2
65.6
high density lipoprotein cholesterol measurement
3
65.6
very low density lipoprotein cholesterol measurement
6
65.1
low density lipoprotein cholesterol measurement
3
54.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nodal modulator 1
454345
Macaque
nodal modulator 1
714226
Mouse
MGI:2385850
211548
Rat
RGD:1305240
361578
Dog
nodal modulator 1
489992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nodal modulator 1
Macaque
nodal modulator 1
Mouse
Rat
Dog
nodal modulator 1
Publication Statistics
PubMed Score 45.30
PubMed score by year
PubTator Score 41.20
PubTator score by year
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Related Publications
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PMID
Year
Title