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Tbio
NOLC1
Nucleolar and coiled-body phosphoprotein 1

Protein Summary
Description
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:10567578, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). Involved in nucleologenesis, possibly by playing a role in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus (PubMed:9016786). It has intrinsic GTPase and ATPase activities (PubMed:9016786).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405356
  • ENSP00000385410
  • ENSG00000166197
  • ENST00000488254
  • ENSP00000475080
  • ENST00000605788
  • ENSP00000474710

Symbol
  • KIAA0035
  • NS5ATP13
  • P130
  • NOPP130
  • NOPP140
  • NS5ATP13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
ligand (protein) perturbation
0.96
transcription factor binding site profile
0.95
transcription factor perturbation
0.94
PubMedID
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.37   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.37   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (294)
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.999849559
p_ni:  0.000150441
Score:  0.185
Data Source:  BioPlex,STRINGDB
DENND2D
Tbio
Novelty:  0.16496649
p_int:  0.999769286
p_ni:  0.000230714
Score:  0.187
Data Source:  BioPlex,STRINGDB
ARRB1
Tbio
Novelty:  0.00262758
p_int:  0.999652607
p_ni:  0.000347393
Score:  0.602
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999360038
p_ni:  0.000639962
Data Source:  BioPlex
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
p_int:  0.998765846
p_ni:  0.001234155
Data Source:  BioPlex
GRK6
Tchem
Family:  Kinase
Novelty:  0.02740874
p_int:  0.998700025
p_ni:  0.001299975
Score:  0.173
Data Source:  BioPlex,STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
p_int:  0.996560391
p_ni:  0.003439609
Score:  0.295
Data Source:  BioPlex,STRINGDB
NOP56
Tbio
Novelty:  0.01256937
p_int:  0.99603831
p_ni:  0.00396169
Score:  0.997
Data Source:  BioPlex,STRINGDB
FGF12
Tbio
Novelty:  0.02094849
p_int:  0.99382303
p_ni:  0.00617697
Data Source:  BioPlex
GTF2IRD1
Tbio
Family:  TF
Novelty:  0.01858027
p_int:  0.993197556
p_ni:  0.006801033
p_wrong:  0.000001411
Score:  0.19
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
4
7
6.6
95
intelligence
4
7
6
6.2
89.8
mathematical ability
3
2
3
87.4
mean reticulocyte volume
1
2
2
81.6
mean corpuscular volume
1
1
1
77.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
7
6.6
95
intelligence
6
6.2
89.8
mathematical ability
3
87.4
mean reticulocyte volume
2
81.6
mean corpuscular volume
1
77.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolar and coiled-body phosphoprotein 1
VGNC:5555
745419
Macaque
nucleolar and coiled-body phosphoprotein 1
712789
Mouse
MGI:1918019
70769
Rat
RGD:621578
64896
Dog
nucleolar and coiled-body phosphoprotein 1
VGNC:43885
609496
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolar and coiled-body phosphoprotein 1
Macaque
nucleolar and coiled-body phosphoprotein 1
Mouse
Rat
Dog
nucleolar and coiled-body phosphoprotein 1
Publication Statistics
PubMed Score 64.37
PubMed score by year
PubTator Score 216.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title