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Tbio
NOL8
Nucleolar protein 8

Protein Summary
Description
Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358855
  • ENSP00000351723
  • ENSG00000198000
  • ENST00000442668
  • ENSP00000401177
  • ENST00000535387
  • ENSP00000441300
  • ENST00000542053
  • ENSP00000440709
  • ENST00000545558
  • ENSP00000441140

Symbol
  • C9orf34
  • NOP132
  • NOP132
  • C9orf34
  • bA62C3.3
  • bA62C3.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.92
drug perturbation
0.87
transcription factor perturbation
0.74
transcription factor binding site profile
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.69   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.69   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
WDR89
Tdark
Novelty:  1.32691886
p_int:  0.999990851
p_ni:  0.000009148
Score:  0.837
Data Source:  BioPlex,STRINGDB
URB1
Tbio
Novelty:  0.04246076
p_int:  0.999911767
p_ni:  0.000088233
Score:  0.907
Data Source:  BioPlex,STRINGDB
URB2
Tbio
Novelty:  0.0837511
p_int:  0.999850268
p_ni:  0.000149732
Score:  0.773
Data Source:  BioPlex,STRINGDB
MECP2
Tchem
Family:  TF
Novelty:  0.00051767
p_int:  0.999703736
p_ni:  0.000296263
p_wrong:  1e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
RPL10A
Tbio
Novelty:  0.01747453
p_int:  0.998696856
p_ni:  0.001303144
Score:  0.536
Data Source:  BioPlex,STRINGDB
DDX51
Tdark
Family:  Enzyme
Novelty:  0.4156824
p_int:  0.998618097
p_ni:  0.001381903
Score:  0.893
Data Source:  BioPlex,STRINGDB
FBL
Tbio
Family:  Enzyme
Novelty:  0.00080634
p_int:  0.995776393
p_ni:  0.004223607
Score:  0.252
Data Source:  BioPlex,STRINGDB
RPL18
Tbio
Novelty:  0.01765545
p_int:  0.965423489
p_ni:  0.034576511
Score:  0.245
Data Source:  BioPlex,STRINGDB
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.961202298
p_ni:  0.038797702
Score:  0.228
Data Source:  BioPlex,STRINGDB
GOPC
Tchem
Novelty:  0.01110168
p_int:  0.91232647
p_ni:  0.08767353
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
2
2
85.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
85.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 8
VGNC:4806
465230
Macaque
nucleolar protein 8
705799
Mouse
MGI:1918180
70930
Rat
RGD:11418826
108348063
Dog
nucleolar protein 8
100684289
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 8
Macaque
nucleolar protein 8
Mouse
Rat
Dog
nucleolar protein 8
Publication Statistics
PubMed Score 3.69
PubMed score by year
PubTator Score 2.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title