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Tbio
NOL7
Nucleolar protein 7

Protein Summary
Description
The protein encoded by this gene localizes to the nucleolus, where it maintains nucleolar structure and cell growth rates. The encoded protein also functions as a tumor suppressor and regulator of angiogenesis. The RB tumor suppressor gene recruits transcription factors to this gene and positively regulates its expression. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000451315
  • ENSP00000405674
  • ENSG00000225921

Symbol
  • C6orf90
  • NOP27
  • PQBP3
  • RARG-1
  • C6orf90
  • dJ223E5.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
kinase perturbation
0.96
histone modification site profile
0.91
transcription factor binding site profile
0.82
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.58   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 25   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.58   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 25   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
WDR75
Tbio
Novelty:  0.09443914
p_int:  0.999986981
p_ni:  0.000013019
Score:  0.795
Data Source:  BioPlex,STRINGDB
CEP120
Tbio
Novelty:  0.07215656
p_int:  0.999978473
p_ni:  0.000021441
p_wrong:  8.6e-8
Score:  0.209
Data Source:  BioPlex,STRINGDB
UTP15
Tbio
Novelty:  0.08174586
p_int:  0.999978002
p_ni:  0.000021998
Score:  0.676
Data Source:  BioPlex,STRINGDB
WDR43
Tbio
Novelty:  0.12680949
p_int:  0.99995558
p_ni:  0.000044114
p_wrong:  3.07e-7
Score:  0.843
Data Source:  BioPlex,STRINGDB
UTP4
Tbio
Novelty:  0.06989008
p_int:  0.997231836
p_ni:  0.002768164
Score:  0.883
Data Source:  BioPlex,STRINGDB
NOL11
Tbio
Novelty:  0.47253767
p_int:  0.996957589
p_ni:  0.003042395
p_wrong:  1.6e-8
Score:  0.765
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.963899096
p_ni:  0.036100904
Data Source:  BioPlex
IPO5
Tbio
Novelty:  0.00452607
p_int:  0.898556015
p_ni:  0.101443985
Score:  0.308
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
Score:  0.928
Data Source:  STRINGDB
MRTO4
Tbio
Novelty:  0.06676322
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
66.1
lymphocyte percentage of leukocytes
1
1
1
18.9
2
1
0
1.1
16.5
neutrophil percentage of leukocytes
1
1
1
11.8
reticulocyte measurement
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
66.1
lymphocyte percentage of leukocytes
1
18.9
0
1.1
16.5
neutrophil percentage of leukocytes
1
11.8
reticulocyte measurement
1
6.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 7
VGNC:3594
462443
Macaque
nucleolar protein 7
701335
Mouse
MGI:1917328
70078
Rat
RGD:1565934
498727
Dog
nucleolar protein 7
VGNC:43884
478727
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 7
Macaque
nucleolar protein 7
Mouse
Rat
Dog
nucleolar protein 7
Publication Statistics
PubMed Score 8.58
PubMed score by year
PubTator Score 5.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title