Tbio NOL6 Nucleolar protein 6

Protein Summary

Description

The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H6R4
• Q5T5M3
• Q5T5M4
• Q7L4G6
• Q8N6I0
• Q8TEY9
• Q8TEZ0
• Q8TEZ1
• Q9H675

Gene Name

• NOL6

Ensembl ID

• ENST00000297990
• ENSP00000297990
• ENSG00000165271
• ENST00000353159
• ENSP00000313978

Symbol

• NRAP
• UTP22
• bA311H10.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.82
cellular component	0.79
transcription factor binding site profile	0.73
histone modification site profile	0.71
tissue sample	0.65

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Nucleolar Protein 6

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Nucleolar Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.63   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.63   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (341)

Explore Interacting Targets

1 – 10 of 341

• See Interactions on String-DB

WDR46

Tbio

Novelty:  0.19307408

p_int:  0.999947579

p_ni:  0.00005242

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

RRP7A

Tbio

Novelty:  0.11315285

p_int:  0.999865422

p_ni:  0.000134507

p_wrong:  7.1e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

NAP1L5

Tbio

Novelty:  0.10378595

p_int:  0.99910631

p_ni:  0.000893686

p_wrong:  4e-9

Score:  0.798

Data Source:  BioPlex,STRINGDB

DGKZ

Tchem

Family:  Enzyme

Novelty:  0.01312044

p_int:  0.997123999

p_ni:  0.002875999

p_wrong:  2e-9

Data Source:  BioPlex

ZBTB48

Tbio

Family:  TF

Novelty:  0.07020518

p_int:  0.980442322

p_ni:  0.019557678

Data Source:  BioPlex

IKZF5

Tbio

Family:  TF

Novelty:  0.36596327

p_int:  0.956944439

p_ni:  0.043055553

p_wrong:  8e-9

Data Source:  BioPlex

NOC2L

Tbio

Novelty:  0.00226536

p_int:  0.950735257

p_ni:  0.049264421

p_wrong:  3.22e-7

Score:  0.997

Data Source:  BioPlex,STRINGDB

RRP8

Tbio

Family:  Enzyme

Novelty:  0.04922797

p_int:  0.950089379

p_ni:  0.049910612

p_wrong:  9e-9

Score:  0.714

Data Source:  BioPlex,STRINGDB

ZNF512

Tbio

Family:  TF

Novelty:  0.08783629

p_int:  0.949738938

p_ni:  0.05026048

p_wrong:  5.82e-7

Score:  0.514

Data Source:  BioPlex,STRINGDB

RPL18A

Tbio

Novelty:  0.04612948

p_int:  0.919879561

p_ni:  0.080117684

p_wrong:  0.000002755

Score:  0.32

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (5)

KEGG (1)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA modification in the nucleus and cytosol	59 targets	R-HSA-6790901
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA modification in the nucleus and cytosol	59 targets	R-HSA-6790901
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (1)

Components (8)

Processes (2)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
albuminuria	EFO_0004285	1	1	1		24.5
glucose measurement	EFO_0004468	1	1	1		6.1
lung adenocarcinoma	EFO_0000571	1	1	0	1.1	1.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
albuminuria	EFO_0004285	1		24.5
glucose measurement	EFO_0004468	1		6.1
lung adenocarcinoma	EFO_0000571	0	1.1	1.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Chromosome
Coiled coil
Complete proteome
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
RNA-binding

GWAS Trait Find Similar Targets

No Header	No Header
albuminuria
glucose measurement
lung adenocarcinoma

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	nucleolar protein 6	VGNC:4805	465047
Macaque	nucleolar protein 6		702596
Mouse	nucleolar protein family 6 (RNA-associated)	MGI:2140151	230082
Dog	nucleolar protein 6	VGNC:43883	481582
Horse	nucleolar protein 6	VGNC:20800	100053901

Species	Name	OMA	EggNOG	Inparanoid
Chimp	nucleolar protein 6
Macaque	nucleolar protein 6
Mouse	nucleolar protein family 6 (RNA-associated)
Dog	nucleolar protein 6
Horse	nucleolar protein 6

Publication Statistics

PubMed Score 12.63

PubMed score by year

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PubTator Score 2.00

PubTator score by year

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Related Publications

Text Mined References (13)

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10

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PMID	Year	Title