Protein Summary
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000297990
- ENSP00000297990
- ENSG00000165271
- ENST00000353159
- ENSP00000313978
- NRAP
- UTP22
- bA311H10.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 0.82 | ||
cellular component | 0.79 | ||
transcription factor binding site profile | 0.73 | ||
histone modification site profile | 0.71 | ||
tissue sample | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.63 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.63 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (341)
WDR46
Novelty: 0.19307408
p_int: 0.999947579
p_ni: 0.00005242
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RRP7A
Novelty: 0.11315285
p_int: 0.999865422
p_ni: 0.000134507
p_wrong: 7.1e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NAP1L5
Novelty: 0.10378595
p_int: 0.99910631
p_ni: 0.000893686
p_wrong: 4e-9
Score: 0.798
Data Source: BioPlex,STRINGDB
DGKZ
Family: Enzyme
Novelty: 0.01312044
p_int: 0.997123999
p_ni: 0.002875999
p_wrong: 2e-9
Data Source: BioPlex
IKZF5
Family: TF
Novelty: 0.36596327
p_int: 0.956944439
p_ni: 0.043055553
p_wrong: 8e-9
Data Source: BioPlex
NOC2L
Novelty: 0.00226536
p_int: 0.950735257
p_ni: 0.049264421
p_wrong: 3.22e-7
Score: 0.997
Data Source: BioPlex,STRINGDB
RRP8
Family: Enzyme
Novelty: 0.04922797
p_int: 0.950089379
p_ni: 0.049910612
p_wrong: 9e-9
Score: 0.714
Data Source: BioPlex,STRINGDB
ZNF512
Family: TF
Novelty: 0.08783629
p_int: 0.949738938
p_ni: 0.05026048
p_wrong: 5.82e-7
Score: 0.514
Data Source: BioPlex,STRINGDB
RPL18A
Novelty: 0.04612948
p_int: 0.919879561
p_ni: 0.080117684
p_wrong: 0.000002755
Score: 0.32
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (5)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Reactome | Metabolism of RNA | ||||
Reactome | rRNA modification in the nucleus and cytosol | ||||
Reactome | rRNA processing | ||||
Reactome | rRNA processing in the nucleus and cytosol | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Major pathway of rRNA processing in the nucleolus and cytosol | ||||
Metabolism of RNA | ||||
rRNA modification in the nucleus and cytosol | ||||
rRNA processing | ||||
rRNA processing in the nucleus and cytosol | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (8)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
albuminuria | 1 | 1 | 1 | 24.5 | |||||
glucose measurement | 1 | 1 | 1 | 6.1 | |||||
1 | 1 | 0 | 1.1 | 1.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
albuminuria | 1 | 24.5 | |||||
glucose measurement | 1 | 6.1 | |||||
0 | 1.1 | 1.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | nucleolar protein 6 | VGNC:4805 | 465047 | |||||
Macaque | nucleolar protein 6 | 702596 | ||||||
Mouse | MGI:2140151 | 230082 | ||||||
Dog | nucleolar protein 6 | VGNC:43883 | 481582 | |||||
Horse | nucleolar protein 6 | VGNC:20800 | 100053901 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | nucleolar protein 6 | |||||
Macaque | nucleolar protein 6 | |||||
Mouse | ||||||
Dog | nucleolar protein 6 | |||||
Horse | nucleolar protein 6 | |||||
Publication Statistics
PubMed Score 12.63
PubMed score by year
PubTator Score 2.00
PubTator score by year
Related Publications
Text Mined References (13)
Items per page:
0 of 0
PMID | Year | Title |
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