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Tbio
NOL6
Nucleolar protein 6

Protein Summary
Description
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297990
  • ENSP00000297990
  • ENSG00000165271
  • ENST00000353159
  • ENSP00000313978

Symbol
  • NRAP
  • UTP22
  • bA311H10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.82
cellular component
0.79
transcription factor binding site profile
0.73
histone modification site profile
0.71
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.63   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.63   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (341)
WDR46
Tbio
Novelty:  0.19307408
p_int:  0.999947579
p_ni:  0.00005242
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRP7A
Tbio
Novelty:  0.11315285
p_int:  0.999865422
p_ni:  0.000134507
p_wrong:  7.1e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
NAP1L5
Tbio
Novelty:  0.10378595
p_int:  0.99910631
p_ni:  0.000893686
p_wrong:  4e-9
Score:  0.798
Data Source:  BioPlex,STRINGDB
DGKZ
Tchem
Family:  Enzyme
Novelty:  0.01312044
p_int:  0.997123999
p_ni:  0.002875999
p_wrong:  2e-9
Data Source:  BioPlex
ZBTB48
Tbio
Family:  TF
Novelty:  0.07020518
p_int:  0.980442322
p_ni:  0.019557678
Data Source:  BioPlex
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.956944439
p_ni:  0.043055553
p_wrong:  8e-9
Data Source:  BioPlex
NOC2L
Tbio
Novelty:  0.00226536
p_int:  0.950735257
p_ni:  0.049264421
p_wrong:  3.22e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.950089379
p_ni:  0.049910612
p_wrong:  9e-9
Score:  0.714
Data Source:  BioPlex,STRINGDB
ZNF512
Tbio
Family:  TF
Novelty:  0.08783629
p_int:  0.949738938
p_ni:  0.05026048
p_wrong:  5.82e-7
Score:  0.514
Data Source:  BioPlex,STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
p_int:  0.919879561
p_ni:  0.080117684
p_wrong:  0.000002755
Score:  0.32
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albuminuria
1
1
1
24.5
glucose measurement
1
1
1
6.1
1
1
0
1.1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albuminuria
1
24.5
glucose measurement
1
6.1
0
1.1
1.1
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 6
VGNC:4805
465047
Macaque
nucleolar protein 6
702596
Mouse
MGI:2140151
230082
Dog
nucleolar protein 6
VGNC:43883
481582
Horse
nucleolar protein 6
VGNC:20800
100053901
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 6
Macaque
nucleolar protein 6
Mouse
Dog
nucleolar protein 6
Horse
nucleolar protein 6
Publication Statistics
PubMed Score 12.63
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title