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Tbio
NOL12
Nucleolar protein 12

Protein Summary
Description
May bind to 28S rRNA.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359114
  • ENSP00000352021
  • ENSG00000273899
  • ENST00000438329
  • ENSP00000403059
  • ENST00000611699
  • ENSP00000482349

Symbol
  • Nop25
  • dJ37E16.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.77
cell type or tissue
0.74
gene perturbation
0.71
transcription factor binding site profile
0.68
tissue sample
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.3   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.3   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
DDX55
Tdark
Family:  Enzyme
Novelty:  0.27887497
p_int:  0.993900913
p_ni:  0.006099062
p_wrong:  2.6e-8
Score:  0.555
Data Source:  BioPlex,STRINGDB
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.993818546
p_ni:  0.006181454
Score:  0.307
Data Source:  BioPlex,STRINGDB
SRSF12
Tbio
Novelty:  0.34992606
p_int:  0.990442512
p_ni:  0.009557484
p_wrong:  4e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
ZNF189
Tdark
Family:  TF
Novelty:  0.28362251
p_int:  0.988797442
p_ni:  0.011192583
p_wrong:  0.000009975
Score:  0.536
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.977666598
p_ni:  0.022333402
Score:  0.322
Data Source:  BioPlex,STRINGDB
ZNF689
Tdark
Family:  TF
Novelty:  1.03726427
p_int:  0.972273541
p_ni:  0.027724849
p_wrong:  0.00000161
Score:  0.239
Data Source:  BioPlex,STRINGDB
MRPS35
Tdark
Novelty:  6.44240335
p_int:  0.966462339
p_ni:  0.033537661
Data Source:  BioPlex
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.962491411
p_ni:  0.037508589
Score:  0.602
Data Source:  BioPlex,STRINGDB
BUD13
Tbio
Novelty:  0.05228416
p_int:  0.960886563
p_ni:  0.039113436
Score:  0.536
Data Source:  BioPlex,STRINGDB
DHX57
Tdark
Family:  Enzyme
Novelty:  0.8244078
p_int:  0.936503914
p_ni:  0.063496086
Score:  0.184
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
2
2
2
67.9
intraocular pressure measurement
4
3
5
67.1
basophil count
2
2
2
58.9
age-related hearing impairment
2
1
1
1.1
52.7
serum albumin measurement
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
2
67.9
intraocular pressure measurement
5
67.1
basophil count
2
58.9
age-related hearing impairment
1
1.1
52.7
serum albumin measurement
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 12
VGNC:12906
742200
Mouse
MGI:2146285
97961
Rat
RGD:1305327
362955
Dog
nucleolar protein 12
608474
Horse
nucleolar protein 12
100054799
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 12
Mouse
Rat
Dog
nucleolar protein 12
Horse
nucleolar protein 12
Publication Statistics
PubMed Score 7.30
PubMed score by year
PubTator Score 1.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title