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Tbio
NOL11
Nucleolar protein 11

Protein Summary
Description
Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253247
  • ENSP00000253247
  • ENSG00000130935
  • ENST00000581375
  • ENSP00000463219
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
kinase perturbation
0.88
transcription factor perturbation
0.88
transcription factor binding site profile
0.84
cell type or tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 29   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.87   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
UTP4
Tbio
Novelty:  0.06989008
p_int:  0.999999611
p_ni:  3.75e-7
p_wrong:  1.4e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
ACSBG1
Tbio
Family:  Enzyme
Novelty:  0.00381436
p_int:  0.999866301
p_ni:  0.000133699
Data Source:  BioPlex
NOL7
Tbio
Novelty:  0.24085052
p_int:  0.996957589
p_ni:  0.003042395
p_wrong:  1.6e-8
Score:  0.765
Data Source:  BioPlex,STRINGDB
PAGE1
Tbio
Novelty:  0.02731969
p_int:  0.99349627
p_ni:  0.00650373
Data Source:  BioPlex
GOLGA4
Tbio
Novelty:  0.01363253
p_int:  0.992185925
p_ni:  0.007814024
p_wrong:  5.1e-8
Score:  0.558
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.991651614
p_ni:  0.008348382
p_wrong:  4e-9
Data Source:  BioPlex
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.98672844
p_ni:  0.01327156
Score:  0.92
Data Source:  BioPlex,STRINGDB
FBXL19
Tbio
Novelty:  0.07526966
p_int:  0.983608711
p_ni:  0.016391289
Data Source:  BioPlex
CDKN3
Tbio
Family:  Enzyme
Novelty:  0.00093913
p_int:  0.978300193
p_ni:  0.021699807
Data Source:  BioPlex
ARSI
Tbio
Family:  Enzyme
Novelty:  0.04002595
p_int:  0.967184222
p_ni:  0.032815694
p_wrong:  8.4e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
2
1.1
87.6
grip strength measurement
2
2
2
79.2
body fat percentage
1
1
1
29
1
1
0
27.4
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
87.6
grip strength measurement
2
79.2
body fat percentage
1
29
0
27.4
17.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 11
VGNC:9478
455270
Macaque
nucleolar protein 11
718803
Mouse
MGI:1916229
68979
Rat
RGD:1584081
688885
Dog
nucleolar protein 11
VGNC:43881
610846
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nucleolar protein 11
Macaque
nucleolar protein 11
Mouse
Rat
Dog
nucleolar protein 11
Publication Statistics
PubMed Score 2.87
PubMed score by year
PubTator Score 1.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title