Protein Summary
Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (PubMed:21976273, PubMed:26643732). The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse kn ...more
- ENST00000332822
- ENSP00000328181
- ENSG00000183691
- SYM1
- SYNS1
- SYNS1A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
gene perturbation | 0.94 | ||
phenotype | 0.91 | ||
transcription factor binding site profile | 0.75 | ||
biological term | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 925.53 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 485 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 925.53 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 485 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 60
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (227)
QTRT1
Family: Enzyme
Novelty: 0.04387363
p_int: 0.999903192
p_ni: 0.000027801
p_wrong: 0.000069007
Data Source: BioPlex
TRIP4
Novelty: 0.06089355
p_int: 0.999772914
p_ni: 0.000226038
p_wrong: 0.000001048
Data Source: BioPlex
TCAF2
Family: Enzyme
Novelty: 0.37070492
p_int: 0.999758773
p_ni: 0.000241227
Data Source: BioPlex
ASCC2
Novelty: 0.12261896
p_int: 0.999571127
p_ni: 0.000428872
p_wrong: 1e-9
Data Source: BioPlex
HTRA1
Family: Enzyme
Novelty: 0.0016879
p_int: 0.998611655
p_ni: 0.000669766
p_wrong: 0.000718579
Data Source: BioPlex
AMER1
Novelty: 0.00951499
p_int: 0.998209205
p_ni: 0.0014889
p_wrong: 0.000301895
Data Source: BioPlex
ITIH2
Novelty: 0.04886358
p_int: 0.996284773
p_ni: 0.003611355
p_wrong: 0.000103872
Data Source: BioPlex
Nearest Tclin Targets
Pathways (12)
Reactome (3)
KEGG (1)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Signal Transduction | ||||
Reactome | Signaling by BMP | ||||
Reactome | Signaling by TGF-beta family members | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Signal Transduction | ||||
Signaling by BMP | ||||
Signaling by TGF-beta family members | ||||
Viral Interactions (0)
Gene Ontology Terms (62)
Functions (2)
Components (2)
Processes (58)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
refractive error measurement | 2 | 2 | 1 | 7 | 32.7 | ||||
age at onset | 1 | 1 | 0 | 7 | 10.4 | ||||
Myopia | 1 | 1 | 0 | 7 | 10.4 | ||||
BMI-adjusted waist circumference | 2 | 3 | 3 | 9.8 | |||||
balding measurement | 1 | 1 | 1 | 4.3 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
refractive error measurement | 1 | 7 | 32.7 | ||||
age at onset | 0 | 7 | 10.4 | ||||
Myopia | 0 | 7 | 10.4 | ||||
BMI-adjusted waist circumference | 3 | 9.8 | |||||
balding measurement | 1 | 4.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | noggin | VGNC:9602 | 468413 | |||||
Macaque | noggin | 707338 | ||||||
Mouse | MGI:104327 | 18121 | ||||||
Rat | RGD:3183 | 25495 | ||||||
Dog | noggin [Source:HGNC Symbol;Acc:HGNC:7866] | |||||||
Publication Statistics
PubMed Score 925.53
PubMed score by year
PubTator Score 314.92
PubTator score by year
Related Publications
Text Mined References (96)
GeneRif Annotations (59)
Items per page:
0 of 0
PMID | Year | Title |
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