Tclin NOD2 Nucleotide-binding oligomerization domain-containing protein 2

Protein Summary

Description

Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed:20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling/MAVS, leading to activation of interferon regulatory factor-3/IRF3 and expression of type I interferon (PubMed:19701189). This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Uniprot Accession IDs

• Q9HC29
• E2JEQ6
• Q96RH5
• Q96RH6
• Q96RH8

Gene Name

• NOD2

Ensembl ID

• ENST00000300589
• ENSP00000300589
• ENSG00000167207
• ENST00000647318
• ENSP00000495993

Symbol

• CARD15
• IBD1
• CD
• ACUG
• BLAU
• IBD1
• YAOS
• BLAUS
• NLRC2
• NOD2B
• CARD15
• CLR16.3
• PSORAS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	1
molecular function	0.95
virus perturbation	0.83
phenotype	0.77

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Nucleotide-binding Oligomerization Domain-containing Protein 2

Protein / Nucleic Acid Binding / Nucleotide-binding Oligomerization Domain-containing Protein 2

Protein / ... / Serine Protease / Nucleotide-binding Oligomerization Domain-containing Protein 2

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Nucleotide-binding Oligomerization Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2062.86   (req: < 5)

Gene RIFs: 692   (req: <= 3)

Antibodies: 456   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2062.86   (req: >= 5)

Gene RIFs: 692   (req: > 3)

Antibodies: 456   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 63

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 91

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1