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Tbio
NOCT
Nocturnin

Protein Summary
Description
Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leading to their degradation and suppression of translation. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance. Promotes adipogenesis by activating PPARG transcriptional activity in a deadenylase-independent manner by facilitating its nuclear translocation. Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone. Critical for proper development of early embryos (By similarity). The protein encoded by this gene is highly similar to Nocturnin, a ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280614
  • ENSP00000280614
  • ENSG00000151014

Symbol
  • CCR4
  • CCRN4L
  • NOC
  • NOC
  • CCR4L
  • Ccr4c
  • CCRN4L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.83   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.83   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
CHRM3
Tclin
Family:  GPCR
Novelty:  0.00849776
p_int:  0.999635278
p_ni:  0.000364722
Data Source:  BioPlex
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.99556319
p_ni:  0.00443681
Data Source:  BioPlex
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.979344088
p_ni:  0.020655809
p_wrong:  1.03e-7
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.973717073
p_ni:  0.026282916
p_wrong:  1.1e-8
Data Source:  BioPlex
PINX1
Tbio
Family:  TF
Novelty:  0.01237398
p_int:  0.972707836
p_ni:  0.027290677
p_wrong:  0.000001488
Data Source:  BioPlex
RAB8B
Tbio
Family:  Enzyme
Novelty:  0.06230082
p_int:  0.970970537
p_ni:  0.029028855
p_wrong:  6.08e-7
Data Source:  BioPlex
HSD17B1
Tchem
Family:  Enzyme
Novelty:  0.00313425
p_int:  0.966310403
p_ni:  0.033672443
p_wrong:  0.000017154
Data Source:  BioPlex
ETNK1
Tbio
Family:  Kinase
Novelty:  0.04817798
p_int:  0.961911935
p_ni:  0.038088064
p_wrong:  1e-9
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.959831742
p_ni:  0.04014721
p_wrong:  0.000021048
Score:  0.25
Data Source:  BioPlex,STRINGDB
PDCD1
Tclin
Novelty:  0.000448
p_int:  0.93995072
p_ni:  0.06004928
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nocturnin
VGNC:13080
100611804
Macaque
nocturnin
100428993
Mouse
MGI:109382
12457
Rat
RGD:1587344
310395
Dog
nocturnin
VGNC:43876
483818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nocturnin
Macaque
nocturnin
Mouse
Rat
Dog
nocturnin
Publication Statistics
PubMed Score 68.83
PubMed score by year
PubTator Score 155.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title