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Tdark
NOC4L
Nucleolar complex protein 4 homolog

IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (357)
BYSL
Tbio
Novelty:  0.01919968
p_int:  0.999988569
p_ni:  0.000011365
p_wrong:  6.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.999983568
p_ni:  0.000016432
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999222441
p_ni:  0.000777559
Data Source:  BioPlex
SEC31A
Tbio
Novelty:  0.0350228
p_int:  0.996188114
p_ni:  0.003811884
p_wrong:  2e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.996068553
p_ni:  0.003931447
p_wrong:  1e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.995867732
p_ni:  0.004132268
Score:  0.186
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.993996846
p_ni:  0.006003154
Score:  0.947
Data Source:  BioPlex,STRINGDB
ZNF324B
Tdark
Family:  TF
Novelty:  1.89922228
p_int:  0.993447536
p_ni:  0.006552464
Score:  0.158
Data Source:  BioPlex,STRINGDB
RPS14
Tbio
Novelty:  0.00576737
p_int:  0.968656412
p_ni:  0.031343587
Score:  0.976
Data Source:  BioPlex,STRINGDB
STX7
Tbio
Novelty:  0.03109969
p_int:  0.947274522
p_ni:  0.052725321
p_wrong:  1.57e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
59
2
2
2
47.5
mean corpuscular volume
1
1
1
44.2
body mass index
1
1
1
28.1
pulmonary function measurement
1
1
0
7.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
59
2
47.5
mean corpuscular volume
1
44.2
body mass index
1
28.1
pulmonary function measurement
0
7.1
21.5
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nucleolar complex associated 4 homolog
710207
Mouse
MGI:2140843
100608
Rat
RGD:1310661
360828
Dog
nucleolar complex associated 4 homolog
VGNC:43875
486225
Horse
nucleolar complex associated 4 homolog
VGNC:20794
100146920
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nucleolar complex associated 4 homolog
Mouse
Rat
Dog
nucleolar complex associated 4 homolog
Horse
nucleolar complex associated 4 homolog
Publication Statistics
PubMed Score 3.92
PubMed score by year
PubTator Score 1.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title