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Tchem
NNMT
Nicotinamide N-methyltransferase

Protein Summary
Description
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299964
  • ENSP00000299964
  • ENSG00000166741
  • ENST00000535401
  • ENSP00000441434
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.84
small molecule perturbation
0.81
disease
0.63
gene perturbation
0.59
transcription factor
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.35   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 429   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.35   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 429   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (43)
CAVIN1
Tbio
Family:  Enzyme
Novelty:  0.00780634
Score:  0.984
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.954
Data Source:  STRINGDB
AOX1
Tchem
Family:  Enzyme
Novelty:  0.0025823
Score:  0.954
Data Source:  STRINGDB
FHL2
Tbio
Novelty:  0.00501273
Score:  0.951
Data Source:  STRINGDB
S100A10
Tbio
Novelty:  0.00281525
Score:  0.942
Data Source:  STRINGDB
NAMPT
Tchem
Family:  Enzyme
Novelty:  0.00093316
Score:  0.936
Data Source:  STRINGDB
CD38
Tclin
Family:  Enzyme
Novelty:  0.00034991
Score:  0.923
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.914
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.911
Data Source:  STRINGDB
AKAP12
Tbio
Family:  Enzyme
Novelty:  0.00821862
Score:  0.76
Data Source:  STRINGDB
Pathways (17)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Reactome
Metabolism of vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Biological oxidations
Metabolism
Metabolism of amino acids and derivatives
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Metabolism of vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
1
2
72.5
mean platelet volume
1
1
1
66.8
platelet count
1
1
1
65.5
2
1
0
1.2
52.7
1
1
0
1.2
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
72.5
mean platelet volume
1
66.8
platelet count
1
65.5
0
1.2
52.7
0
1.2
52.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nicotinamide N-methyltransferase
VGNC:3092
451558
Macaque
nicotinamide N-methyltransferase
695185
Mouse
MGI:1099443
18113
Rat
RGD:1309606
300691
Dog
nicotinamide N-methyltransferase
VGNC:43869
489396
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nicotinamide N-methyltransferase
Macaque
nicotinamide N-methyltransferase
Mouse
Rat
Dog
nicotinamide N-methyltransferase
Publication Statistics
PubMed Score 216.35
PubMed score by year
PubTator Score 117.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title