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Tchem
NMT1
Glycylpeptide N-tetradecanoyltransferase 1

Protein Summary
Description
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258960
  • ENSP00000258960
  • ENSG00000136448
  • ENST00000592782
  • ENSP00000468424

Symbol
  • NMT
  • NMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
virus perturbation
1
kinase perturbation
0.84
transcription factor binding site profile
0.83
transcription factor perturbation
0.8


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 454.42   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 454.42   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 244
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0