You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NMRK2
Nicotinamide riboside kinase 2

Protein Summary
Description
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000168977
  • ENSP00000168977
  • ENSG00000077009
  • ENST00000593949
  • ENSP00000472581
  • ENST00000616156
  • ENSP00000480091

Symbol
  • ITGB1BP3
  • NRK2
  • MIBP
  • NRK2
  • ITGB1BP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
gene perturbation
0.53
biological process
0.51
cell type or tissue
0.5
tissue
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.46   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.46   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
NAPRT
Tchem
Family:  Enzyme
Novelty:  0.0307992
Score:  0.963
Data Source:  STRINGDB
NMNAT3
Tbio
Family:  Enzyme
Novelty:  0.03261313
Score:  0.954
Data Source:  STRINGDB
NMNAT2
Tbio
Family:  Enzyme
Novelty:  0.01709189
Score:  0.951
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.947
Data Source:  STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.946
Data Source:  STRINGDB
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
Score:  0.942
Data Source:  STRINGDB
NAMPT
Tchem
Family:  Enzyme
Novelty:  0.00093316
Score:  0.94
Data Source:  STRINGDB
ITGA7
Tbio
Novelty:  0.01243073
Score:  0.927
Data Source:  STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
Score:  0.902
Data Source:  STRINGDB
ENPP3
Tchem
Family:  Enzyme
Novelty:  0.00414129
Score:  0.9
Data Source:  STRINGDB
Pathways (35)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
65.6
body mass index
1
1
1
65.4
glomerular filtration rate
1
1
1
5.8
creatinine measurement
1
1
1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
65.6
body mass index
1
65.4
glomerular filtration rate
1
5.8
creatinine measurement
1
5.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nicotinamide riboside kinase 2
721792
Mouse
MGI:1916814
69564
Rat
RGD:6486791
100912521
Horse
nicotinamide riboside kinase 2
VGNC:20783
100630136
Opossum
nicotinamide riboside kinase 2
100617964
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nicotinamide riboside kinase 2
Mouse
Rat
Horse
nicotinamide riboside kinase 2
Opossum
nicotinamide riboside kinase 2
Publication Statistics
PubMed Score 12.46
PubMed score by year
PubTator Score 26.68
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title