You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NMNAT3
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3

Protein Summary
Description
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury. This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296202
  • ENSP00000296202
  • ENSG00000163864
  • ENST00000339837
  • ENSP00000340523
  • ENST00000413939
  • ENSP00000412953

Symbol
  • PNAT3
  • FKSG76
  • PNAT-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
tissue sample
0.73
histone modification site profile
0.62
pathway
0.6
PubMedID
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.77   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.77   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
DCX
Tbio
Novelty:  0.00077614
p_int:  0.999995348
p_ni:  2.45e-7
p_wrong:  0.000004408
Score:  0.543
Data Source:  BioPlex,STRINGDB
HS2ST1
Tbio
Family:  Enzyme
Novelty:  0.04520207
p_int:  0.999800202
p_ni:  0.000016053
p_wrong:  0.000183745
Score:  0.228
Data Source:  BioPlex,STRINGDB
SPTB
Tbio
Novelty:  0.00467504
p_int:  0.999466128
p_ni:  0.000036163
p_wrong:  0.000497708
Score:  0.218
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.917292897
p_ni:  0.082707103
Data Source:  BioPlex
NADSYN1
Tbio
Family:  Enzyme
Novelty:  0.0445844
Score:  0.981
Data Source:  STRINGDB
NADK
Tbio
Family:  Kinase
Novelty:  0.02812925
Score:  0.974
Data Source:  STRINGDB
NAPRT
Tchem
Family:  Enzyme
Novelty:  0.0307992
Score:  0.973
Data Source:  STRINGDB
NAMPT
Tchem
Family:  Enzyme
Novelty:  0.00093316
Score:  0.971
Data Source:  STRINGDB
NMRK1
Tbio
Family:  Kinase
Novelty:  0.04761376
Score:  0.969
Data Source:  STRINGDB
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
Score:  0.963
Data Source:  STRINGDB
Pathways (15)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
3
3
52.2
gut microbiome measurement
1
1
0
5.6
42.5
substance abuse
1
1
1
21.2
antisocial behaviour measurement
1
1
1
21.2
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
3
52.2
gut microbiome measurement
0
5.6
42.5
substance abuse
1
21.2
antisocial behaviour measurement
1
21.2
1
21.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nicotinamide nucleotide adenylyltransferase 3
VGNC:2449
460735
Macaque
nicotinamide nucleotide adenylyltransferase 3
106992359
Mouse
MGI:1921330
74080
Dog
nicotinamide nucleotide adenylyltransferase 3
VGNC:43864
477091
Horse
nicotinamide nucleotide adenylyltransferase 3
VGNC:20781
100146546
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nicotinamide nucleotide adenylyltransferase 3
Macaque
nicotinamide nucleotide adenylyltransferase 3
Mouse
Dog
nicotinamide nucleotide adenylyltransferase 3
Horse
nicotinamide nucleotide adenylyltransferase 3
Publication Statistics
PubMed Score 36.77
PubMed score by year
PubTator Score 8.41
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title