Tbio NMNAT2 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

Protein Summary

Description

Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity). This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9BZQ4
• O75067
• Q5T1Q3
• Q8WU99
• Q96QW1
• NMN/NaMN adenylyltransferase 2

Gene Name

• NMNAT2

Ensembl ID

• ENST00000287713
• ENSP00000287713
• ENSG00000157064
• ENST00000294868
• ENSP00000294868

Symbol

• C1orf15
• KIAA0479
• PNAT2
• C1orf15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
transcription factor	0.8
gene perturbation	0.74
microRNA	0.68
PubMedID	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Nicotinamide/nicotinic Acid Mononucleotide Adenylyltransferase 2

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Nicotinamide/nicotinic Acid Mononucleotide Adenylyltransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.76   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 149   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 86.76   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0