You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NMNAT2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

Protein Summary
Description
Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PubMed:16118205, PubMed:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PubMed:16118205, PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:16118205, PubMed:17402747). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PubMed:16118205, PubMed:17402747). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:16118205, PubMed:17402747). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon deg ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287713
  • ENSP00000287713
  • ENSG00000157064
  • ENST00000294868
  • ENSP00000294868

Symbol
  • C1orf15
  • KIAA0479
  • PNAT2
  • C1orf15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
transcription factor
0.8
gene perturbation
0.74
microRNA
0.68
PubMedID
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.62   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.62   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
NADSYN1
Tbio
Family:  Enzyme
Novelty:  0.0445844
Score:  0.98
Data Source:  STRINGDB
NADK
Tbio
Family:  Kinase
Novelty:  0.02812925
Score:  0.973
Data Source:  STRINGDB
NAPRT
Tchem
Family:  Enzyme
Novelty:  0.0307992
Score:  0.972
Data Source:  STRINGDB
NAMPT
Tchem
Family:  Enzyme
Novelty:  0.00093316
Score:  0.966
Data Source:  STRINGDB
NMRK1
Tbio
Family:  Kinase
Novelty:  0.04761376
Score:  0.962
Data Source:  STRINGDB
QPRT
Tbio
Family:  Enzyme
Novelty:  0.00781554
Score:  0.955
Data Source:  STRINGDB
NMRK2
Tbio
Family:  Kinase
Novelty:  0.11112212
Score:  0.951
Data Source:  STRINGDB
CD38
Tclin
Family:  Enzyme
Novelty:  0.00034991
Score:  0.922
Data Source:  STRINGDB
NNT
Tbio
Family:  Enzyme
Novelty:  0.00269343
Score:  0.922
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.92
Data Source:  STRINGDB
Pathways (29)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
2
0
1.2
83.6
1
1
0
1.6
81.9
neutrophil count
2
1
2
58.4
myeloid white cell count
1
1
1
57.3
heel bone mineral density
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1.2
83.6
0
1.6
81.9
neutrophil count
2
58.4
myeloid white cell count
1
57.3
heel bone mineral density
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nicotinamide nucleotide adenylyltransferase 2
VGNC:11559
743583
Macaque
nicotinamide nucleotide adenylyltransferase 2
717648
Mouse
MGI:2444155
226518
Rat
RGD:1307331
289095
Dog
nicotinamide nucleotide adenylyltransferase 2
VGNC:43863
610576
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nicotinamide nucleotide adenylyltransferase 2
Macaque
nicotinamide nucleotide adenylyltransferase 2
Mouse
Rat
Dog
nicotinamide nucleotide adenylyltransferase 2
Publication Statistics
PubMed Score 71.62
PubMed score by year
PubTator Score 24.32
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title