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Tbio
NMNAT1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

Protein Summary
Description
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (PubMed:17402747). Can use triazofurin monophosphate (TrMP) as substrate (PubMed:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (PubMed:17402747). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (PubMed:17402747). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (PubMed:17402747). Protects against axonal degeneration following mecha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377205
  • ENSP00000366410
  • ENSG00000173614
  • ENST00000462686
  • ENSP00000435134

Symbol
  • NMNAT
  • LCA9
  • NMNAT
  • PNAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
molecular function
0.91
virus perturbation
0.9
protein complex
0.72
transcription factor binding site profile
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.77   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.77   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
PCYT1A
Tchem
Family:  Enzyme
Novelty:  0.00621528
p_int:  0.999842116
p_ni:  0.000157884
Score:  0.594
Data Source:  BioPlex,STRINGDB
RRP8
Tbio
Family:  Enzyme
Novelty:  0.04922797
p_int:  0.992922982
p_ni:  0.007077018
Score:  0.662
Data Source:  BioPlex,STRINGDB
NPM1
Tbio
Novelty:  0.0005485
p_int:  0.991369088
p_ni:  0.008630912
Data Source:  BioPlex
KNOP1
Tdark
Novelty:  0.5609503
p_int:  0.987796316
p_ni:  0.012203684
Score:  0.547
Data Source:  BioPlex,STRINGDB
STAU1
Tbio
Novelty:  0.00565778
p_int:  0.984720767
p_ni:  0.015279233
Score:  0.71
Data Source:  BioPlex,STRINGDB
CDCA4
Tbio
Novelty:  0.04549061
p_int:  0.978261419
p_ni:  0.021738563
p_wrong:  1.8e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.973005684
p_ni:  0.026994316
Data Source:  BioPlex
DGCR8
Tbio
Novelty:  0.00271221
p_int:  0.970899938
p_ni:  0.029100061
p_wrong:  1e-9
Data Source:  BioPlex
H1FOO
Tbio
Novelty:  0.02189067
p_int:  0.970577713
p_ni:  0.029420615
p_wrong:  0.000001672
Data Source:  BioPlex
PLEKHO1
Tbio
Novelty:  0.01658553
p_int:  0.9375456
p_ni:  0.062454399
Data Source:  BioPlex
Pathways (27)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
50.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
50.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
nicotinamide nucleotide adenylyltransferase 1
722599
Mouse
MGI:1913704
66454
Rat
RGD:1310996
298653
Dog
nicotinamide nucleotide adenylyltransferase 1
VGNC:43862
100856724
Horse
nicotinamide nucleotide adenylyltransferase 1
VGNC:20780
100057371
Species
Name
OMA
EggNOG
Inparanoid
Macaque
nicotinamide nucleotide adenylyltransferase 1
Mouse
Rat
Dog
nicotinamide nucleotide adenylyltransferase 1
Horse
nicotinamide nucleotide adenylyltransferase 1
Publication Statistics
PubMed Score 91.77
PubMed score by year
PubTator Score 77.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title