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Tbio
NME4
Nucleoside diphosphate kinase, mitochondrial

Protein Summary
Description
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219479
  • ENSP00000219479
  • ENSG00000103202
  • ENST00000397722
  • ENSP00000380834
  • ENST00000450036
  • ENSP00000389048
  • ENST00000620944
  • ENSP00000479996

Symbol
  • NM23D
  • NDPK-D
  • NM23H4
  • nm23-H4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor perturbation
0.8
cellular component
0.76
gene perturbation
0.74
biological process
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.98   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.98   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0