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Tbio
NME3
Nucleoside diphosphate kinase 3

Protein Summary
Description
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219302
  • ENSP00000219302
  • ENSG00000103024

Symbol
  • NDPKC
  • NDPK-C
  • NM23H3
  • DR-nm23
  • NM23-H3
  • c371H6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
cell type or tissue
0.8
biological process
0.73
pathway
0.69
cellular component
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.13   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.13   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0