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Tbio
NME3
Nucleoside diphosphate kinase 3

Protein Summary
Description
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000219302
  • ENSP00000219302
  • ENSG00000103024

Symbol
  • NDPKC
  • NDPK-C
  • NM23H3
  • DR-nm23
  • NM23-H3
  • c371H6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
cell type or tissue
0.8
biological process
0.73
pathway
0.69
cellular component
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.67   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.67   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
NME2
Tbio
Family:  Kinase
Novelty:  0.00257937
p_int:  0.999999986
p_ni:  1e-8
p_wrong:  4e-9
Score:  0.875
Data Source:  BioPlex,STRINGDB
NME2P1
Tdark
Family:  Kinase
p_int:  0.999994206
p_ni:  0.000005657
p_wrong:  1.36e-7
Data Source:  BioPlex
BBS5
Tbio
Novelty:  0.04208041
p_int:  0.999989837
p_ni:  0.000010143
p_wrong:  1.9e-8
Score:  0.857
Data Source:  BioPlex,STRINGDB
BBS9
Tbio
Novelty:  0.01879869
p_int:  0.999985179
p_ni:  0.000014821
Score:  0.816
Data Source:  BioPlex,STRINGDB
NME4
Tbio
Family:  Kinase
Novelty:  0.03735196
p_int:  0.999977922
p_ni:  0.000022078
Score:  0.847
Data Source:  BioPlex,STRINGDB
BBS4
Tbio
Novelty:  0.01825873
p_int:  0.9999535
p_ni:  0.000046494
p_wrong:  6e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
TTC8
Tbio
Novelty:  0.08520636
p_int:  0.999740155
p_ni:  0.000259728
p_wrong:  1.18e-7
Score:  0.829
Data Source:  BioPlex,STRINGDB
EXD2
Tbio
Family:  Enzyme
Novelty:  0.09804411
p_int:  0.996652702
p_ni:  0.003347298
Score:  0.206
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.98983634
p_ni:  0.01016366
Score:  0.577
Data Source:  BioPlex,STRINGDB
BBS2
Tbio
Novelty:  0.00835161
p_int:  0.978858598
p_ni:  0.021141402
Score:  0.808
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
GUCY1B1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
GUCY2C
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
GUCY1A1
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (27)
Interconversion of nucleotide di- and triphosphates (R-HSA-499943)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Interconversion of nucleotide di- and triphosphates
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Name
Explore in Pharos
Explore in Source
Interconversion of nucleotide di- and triphosphates
Metabolism
Metabolism of nucleotides
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
7
7
98.8
appendicular lean mass
3
1
3
75.7
sex hormone-binding globulin measurement
2
1
2
56.4
blood metabolite measurement
1
1
1
49.5
platelet crit
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
7
98.8
appendicular lean mass
3
75.7
sex hormone-binding globulin measurement
2
56.4
blood metabolite measurement
1
49.5
platelet crit
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 nucleoside diphosphate kinase 3
VGNC:13748
467867
Macaque
NME/NM23 nucleoside diphosphate kinase 3
722479
Mouse
MGI:1930182
79059
Rat
RGD:619879
85269
Dog
NME/NM23 nucleoside diphosphate kinase 3
VGNC:54050
100856596
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NME/NM23 nucleoside diphosphate kinase 3
Macaque
NME/NM23 nucleoside diphosphate kinase 3
Mouse
Rat
Dog
NME/NM23 nucleoside diphosphate kinase 3
Publication Statistics
PubMed Score 18.67
PubMed score by year
PubTator Score 42.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title