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Tbio
NMD3
60S ribosomal export protein NMD3

Protein Summary
Description
Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit. Ribosomal 40S and 60S subunits associate in the nucleolus and are exported to the cytoplasm. The protein encoded by this gene is involved in the passage of the 60S subunit through the nuclear pore complex and into the cytoplasm. Several transcript variants exist for this gene, but the full-length natures of only two have been described to date. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000351193
  • ENSP00000307525
  • ENSG00000169251
  • ENST00000460469
  • ENSP00000419004

Symbol
  • CGI-07
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
drug perturbation
0.71
microRNA
0.69
virus perturbation
0.64
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.83   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (369)
GSTT2B
Tbio
Family:  Enzyme
Novelty:  0.02334158
p_int:  0.999969244
p_ni:  0.000030756
Score:  0.28
Data Source:  BioPlex,STRINGDB
HMMR
Tchem
Novelty:  0.0039196
p_int:  0.999358877
p_ni:  0.000641123
Score:  0.561
Data Source:  BioPlex,STRINGDB
ST8SIA1
Tbio
Family:  Enzyme
Novelty:  0.02322808
p_int:  0.999284968
p_ni:  0.000715031
p_wrong:  2e-9
Score:  0.787
Data Source:  BioPlex,STRINGDB
DTX3
Tbio
Family:  Enzyme
Novelty:  0.06212096
p_int:  0.998897526
p_ni:  0.001102472
p_wrong:  2e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
POTEF
Tbio
Novelty:  0.00191599
p_int:  0.986647343
p_ni:  0.013352657
Score:  0.19
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.980295964
p_ni:  0.015683399
p_wrong:  0.004020637
Data Source:  BioPlex
SGSH
Tbio
Family:  Enzyme
Novelty:  0.00670111
p_int:  0.978359843
p_ni:  0.020909816
p_wrong:  0.000730341
Data Source:  BioPlex
GPD1
Tbio
Family:  Enzyme
Novelty:  0.00584133
p_int:  0.971255185
p_ni:  0.02836873
p_wrong:  0.000376085
Score:  0.193
Data Source:  BioPlex,STRINGDB
SFTA2
Tdark
Novelty:  0.24469271
p_int:  0.969732854
p_ni:  0.029770937
p_wrong:  0.000496208
Score:  0.189
Data Source:  BioPlex,STRINGDB
FAM83D
Tbio
Novelty:  0.07381559
p_int:  0.969355902
p_ni:  0.030644098
Score:  0.527
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
4
1
1
80.4
self reported educational attainment
3
3
3
44
risky sexual behaviour measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
80.4
self reported educational attainment
3
44
risky sexual behaviour measurement
1
21.5
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NMD3 ribosome export adaptor
VGNC:2448
460825
Macaque
NMD3 ribosome export adaptor
701677
Mouse
MGI:2140103
97112
Rat
RGD:1308468
310512
Dog
NMD3 ribosome export adaptor
VGNC:43856
488137
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NMD3 ribosome export adaptor
Macaque
NMD3 ribosome export adaptor
Mouse
Rat
Dog
NMD3 ribosome export adaptor
Publication Statistics
PubMed Score 33.83
PubMed score by year
PubTator Score 8.40
PubTator score by year
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Related Publications
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PMID
Year
Title