Tchem NMBR Neuromedin-B receptor

Protein Summary

Description

Receptor for neuromedin-B. This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• P28336
• E9KL38
• Q5VUK8
• NMB-R

Gene Name

• NMBR

Ensembl ID

• ENST00000258042
• ENSP00000258042
• ENSG00000135577

Symbol

• BB1
• BB1R
• NMB-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
ligand (chemical)	0.74
cell type or tissue	0.69
disease perturbation	0.68
protein domain	0.58

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Bombesin Receptor / Neuromedin-b Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.73   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 260   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.73   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0