Protein Summary
Stimulates smooth muscle contraction in a manner similar to that of bombesin. This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
- ENST00000360476
- ENSP00000353664
- ENSG00000197696
- ENST00000394588
- ENSP00000378089
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.76 | ||
gene perturbation | 0.66 | ||
histone modification site profile | 0.66 | ||
biological process | 0.62 | ||
tissue sample | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.09 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 142 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 126.09 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 142 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (194)
NIPBL
Novelty: 0.00462654
p_int: 0.999894293
p_ni: 0.000055671
p_wrong: 0.000050036
Data Source: BioPlex
MAU2
Novelty: 0.00594861
p_int: 0.999806182
p_ni: 0.000079992
p_wrong: 0.000113826
Data Source: BioPlex
RNF123
Family: Enzyme
Novelty: 0.01872044
p_int: 0.999196716
p_ni: 0.000803284
Data Source: BioPlex
ZMYND19
Novelty: 0.3590069
p_int: 0.983619509
p_ni: 0.016380379
p_wrong: 1.13e-7
Data Source: BioPlex
XRCC2
Novelty: 0.00862049
p_int: 0.893774048
p_ni: 0.000139599
p_wrong: 0.106086353
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (7)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Peptide ligand-binding receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Peptide ligand-binding receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (2)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 2 | 5 | 5 | 85.1 | |||||
5 | 4 | 1 | 1.1 | 76 | |||||
appendicular lean mass | 1 | 1 | 1 | 59.8 | |||||
glomerular filtration rate | 2 | 1 | 2 | 52.7 | |||||
1 | 1 | 0 | 1.1 | 48.5 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 5 | 85.1 | |||||
1 | 1.1 | 76 | |||||
appendicular lean mass | 1 | 59.8 | |||||
glomerular filtration rate | 2 | 52.7 | |||||
0 | 1.1 | 48.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | neuromedin B | VGNC:1908 | 743470 | |||||
Mouse | MGI:1915289 | 68039 | ||||||
Rat | RGD:1562710 | 499194 | ||||||
Dog | neuromedin B | VGNC:43854 | 479051 | |||||
Horse | neuromedin B | VGNC:20772 | 100053292 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | neuromedin B | |||||
Mouse | ||||||
Rat | ||||||
Dog | neuromedin B | |||||
Horse | neuromedin B | |||||
Publication Statistics
PubMed Score 126.09
PubMed score by year
PubTator Score 138.04
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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