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Tbio
NLRP7
NACHT, LRR and PYD domains-containing protein 7

Protein Summary
Description
Inhibits CASP1/caspase-1-dependent IL1B secretion. This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328092
  • ENSP00000329568
  • ENSG00000167634
  • ENST00000340844
  • ENSP00000339491
  • ENST00000588756
  • ENSP00000467123
  • ENST00000590030
  • ENSP00000465520
  • ENST00000592784
  • ENSP00000468706
  • ENST00000610424
  • ENSP00000482887
  • ENSG00000274571
  • ENST00000610790
  • ENSP00000478726
  • ENST00000610853
  • ENSP00000478890
  • ENST00000610981
  • ENSP00000479459
  • ENSG00000277776
  • ENST00000611597
  • ENSP00000481117
  • ENST00000613233
  • ENSP00000483203
  • ENST00000614879
  • ENSP00000484444
  • ENSG00000277071
  • ENST00000615426
  • ENSP00000484426
  • ENST00000615699
  • ENSP00000480449
  • ENSG00000277786
  • ENST00000618261
  • ENSP00000483353
  • ENSG00000277179
  • ENST00000618343
  • ENSP00000480226
  • ENSG00000274174
  • ENST00000618672
  • ENSP00000481452
  • ENST00000618740
  • ENSP00000484808
  • ENST00000618995
  • ENSP00000481809
  • ENSG00000276804
  • ENST00000620183
  • ENSP00000480034
  • ENST00000620820
  • ENSP00000482551
  • ENST00000621238
  • ENSP00000481395
  • ENST00000621584
  • ENSP00000479541
  • ENSG00000275483
  • ENST00000622199
  • ENSP00000482194

Symbol
  • NALP7
  • NOD12
  • PYPAF3
  • HYDM
  • PAN7
  • NALP7
  • NOD12
  • PYPAF3
  • CLR19.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
protein domain
0.58
biological term
0.57
cell line
0.52
cellular component
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.6   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.6   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0