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Tchem
NLRP3
NACHT, LRR and PYD domains-containing protein 3

Protein Summary
Description
As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336119
  • ENSP00000337383
  • ENSG00000162711
  • ENST00000348069
  • ENSP00000294752
  • ENST00000366496
  • ENSP00000355452
  • ENST00000366497
  • ENSP00000355453
  • ENST00000391827
  • ENSP00000375703
  • ENST00000391828
  • ENSP00000375704
  • ENST00000474792
  • ENSP00000493937
  • ENST00000643234
  • ENSP00000493674

Symbol
  • C1orf7
  • CIAS1
  • NALP3
  • PYPAF1
  • AII
  • AVP
  • FCU
  • MWS
  • FCAS
  • KEFH
  • CIAS1
  • FCAS1
  • NALP3
  • C1orf7
  • CLR1.1
  • DFNA34
  • PYPAF1
  • AGTAVPRL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
biological process
0.99
protein domain
0.85
molecular function
0.81
phenotype
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3844.01   (req: < 5)
Gene RIFs: 531   (req: <= 3)
Antibodies: 731   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3844.01   (req: >= 5)
Gene RIFs: 531   (req: > 3)
Antibodies: 731   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 58
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1