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Tbio
NLRP11
NACHT, LRR and PYD domains-containing protein 11

Protein Summary
Description
Involved in inflammation. This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000589093
  • ENSP00000466285
  • ENSG00000179873
  • ENST00000589824
  • ENSP00000468082
  • ENST00000592953
  • ENSP00000468196

Symbol
  • NALP11
  • NOD17
  • PAN10
  • PYPAF6
  • NOD17
  • PAN10
  • NALP11
  • PYPAF6
  • PYPAF7
  • CLR19.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cellular component
0.9
phenotype
0.63
trait
0.61
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.683
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.683
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.683
Data Source:  STRINGDB
OR6K2
Tdark
Family:  oGPCR
Novelty:  9.52267303
Score:  0.557
Data Source:  STRINGDB
ZNF563
Tdark
Family:  TF
Novelty:  5.34386694
Score:  0.545
Data Source:  STRINGDB
MEFV
Tbio
Novelty:  0.00074419
Score:  0.543
Data Source:  STRINGDB
OR2T6
Tdark
Family:  oGPCR
Novelty:  5.78866769
Score:  0.515
Data Source:  STRINGDB
OR9G4
Tdark
Family:  oGPCR
Novelty:  8.35908142
Score:  0.491
Data Source:  STRINGDB
OR52M1
Tdark
Family:  oGPCR
Novelty:  3.778697
Score:  0.473
Data Source:  STRINGDB
OR4K15
Tdark
Family:  oGPCR
Novelty:  2.54386907
Score:  0.473
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
2
2
3
77.1
parental genotype effect measurement
1
2
2
65.7
birth weight
1
2
2
65.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
3
77.1
parental genotype effect measurement
2
65.7
birth weight
2
65.7
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NLR family pyrin domain containing 11
704053
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NLR family pyrin domain containing 11
Publication Statistics
PubMed Score 8.65
PubMed score by year
PubTator Score 6.56
PubTator score by year
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Related Publications
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PMID
Year
Title