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Tbio
NLRP1
NACHT, LRR and PYD domains-containing protein 1

Protein Summary
Description
As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262467
  • ENSP00000262467
  • ENSG00000091592
  • ENST00000269280
  • ENSP00000269280
  • ENST00000345221
  • ENSP00000324366
  • ENST00000354411
  • ENSP00000346390
  • ENST00000544378
  • ENSP00000442029
  • ENST00000571451
  • ENSP00000459661
  • ENST00000572272
  • ENSP00000460475
  • ENST00000577119
  • ENSP00000460216
  • ENST00000613500
  • ENSP00000483359
  • ENST00000617618
  • ENSP00000478516
  • ENST00000619223
  • ENSP00000484692

Symbol
  • CARD7
  • DEFCAP
  • KIAA0926
  • NAC
  • NALP1
  • NAC
  • MSPC
  • AIADK
  • CARD7
  • CIDED
  • NALP1
  • SLEV1
  • DEFCAP
  • PP1044
  • VAMAS1
  • CLR17.1
  • DEFCAP-L/S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.92
biological process
0.8
cell type or tissue
0.66
biological term
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.96   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.96   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0