Tbio NLRP1 NACHT, LRR and PYD domains-containing protein 1

Protein Summary

Description

As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762). This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9C000
• E9PE50
• I6L9D9
• Q9BZZ8
• Q9BZZ9
• Q9H5Z7
• Q9H5Z8
• Q9HAV8
• Q9UFT4
• Q9Y2E0

Gene Name

• NLRP1

Ensembl ID

• ENST00000262467
• ENSP00000262467
• ENSG00000091592
• ENST00000269280
• ENSP00000269280
• ENST00000345221
• ENSP00000324366
• ENST00000354411
• ENSP00000346390
• ENST00000544378
• ENSP00000442029
• ENST00000571451
• ENSP00000459661
• ENST00000572272
• ENSP00000460475
• ENST00000577119
• ENSP00000460216
• ENST00000613500
• ENSP00000483359
• ENST00000617618
• ENSP00000478516
• ENST00000619223
• ENSP00000484692

Symbol

• CARD7
• DEFCAP
• KIAA0926
• NAC
• NALP1
• NAC
• MSPC
• AIADK
• CARD7
• CIDED
• NALP1
• SLEV1
• DEFCAP
• PP1044
• VAMAS1
• CLR17.1
• DEFCAP-L/S

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
protein domain	0.92
biological process	0.8
cell type or tissue	0.66
biological term	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.96   (req: < 5)

Gene RIFs: 141   (req: <= 3)

Antibodies: 228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.96   (req: >= 5)

Gene RIFs: 141   (req: > 3)

Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0