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Tbio
NLRC5
Protein NLRC5

Protein Summary
Description
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262510
  • ENSP00000262510
  • ENSG00000140853
  • ENST00000436936
  • ENSP00000389739
  • ENST00000539144
  • ENSP00000441727
  • ENST00000539881
  • ENSP00000441679

Symbol
  • NOD27
  • NOD4
  • NOD4
  • NOD27
  • CLR16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
molecular function
0.96
gene perturbation
0.85
biological process
0.77
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.34   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.34   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.985
Data Source:  Reactome,STRINGDB
IFIH1
Tbio
Family:  Enzyme
Novelty:  0.00111499
Score:  0.974
Data Source:  Reactome,STRINGDB
MAVS
Tbio
Novelty:  0.00241215
Score:  0.962
Data Source:  STRINGDB
TRIM25
Tbio
Family:  Enzyme
Novelty:  0.0045864
Score:  0.931
Data Source:  Reactome,STRINGDB
RNF135
Tbio
Family:  Enzyme
Novelty:  0.05600338
Score:  0.905
Data Source:  Reactome,STRINGDB
TAP1
Tbio
Novelty:  0.02264011
Score:  0.702
Data Source:  STRINGDB
NLRC4
Tbio
Novelty:  0.0032237
Score:  0.699
Data Source:  STRINGDB
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.678
Data Source:  STRINGDB
ZNF267
Tdark
Family:  TF
Novelty:  0.3315203
Score:  0.666
Data Source:  STRINGDB
CHUK
Tchem
Family:  Kinase
Novelty:  0.00151532
Score:  0.638
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (R-HSA-168928)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Negative regulators of DDX58/IFIH1 signaling
Name
Explore in Pharos
Explore in Source
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Negative regulators of DDX58/IFIH1 signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
52
73
182
2.7
100
apolipoprotein A 1 measurement
2
29
29
100
sleep duration
4
17
25
99.9
total cholesterol measurement
13
26
44
2.5
99.4
triglyceride measurement
17
19
41
2.9
99
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
182
2.7
100
apolipoprotein A 1 measurement
29
100
sleep duration
25
99.9
total cholesterol measurement
44
2.5
99.4
triglyceride measurement
41
2.9
99
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NLR family CARD domain containing 5
703437
Mouse
MGI:3612191
434341
Rat
RGD:1309166
291861
Dog
NLR family CARD domain containing 5
VGNC:43844
487268
Horse
NLR family CARD domain containing 5
VGNC:20766
100052017
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NLR family CARD domain containing 5
Mouse
Rat
Dog
NLR family CARD domain containing 5
Horse
NLR family CARD domain containing 5
Publication Statistics
PubMed Score 117.34
PubMed score by year
PubTator Score 42.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title