Protein Summary
Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
- ENST00000262510
- ENSP00000262510
- ENSG00000140853
- ENST00000436936
- ENSP00000389739
- ENST00000539144
- ENSP00000441727
- ENST00000539881
- ENSP00000441679
- NOD27
- NOD4
- NOD4
- NOD27
- CLR16.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
molecular function | 0.96 | ||
gene perturbation | 0.85 | ||
biological process | 0.77 | ||
tissue sample | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.4 (req: < 5)
Gene RIFs: 68 (req: <= 3)
Antibodies: 73 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 135.4 (req: >= 5)
Gene RIFs: 68 (req: > 3)
Antibodies: 73 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0