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Tbio
NLRC4
NLR family CARD domain-containing protein 4

Protein Summary
Description
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity). This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342905
  • ENSP00000339666
  • ENSG00000091106
  • ENST00000360906
  • ENSP00000354159
  • ENST00000402280
  • ENSP00000385428
  • ENST00000404025
  • ENSP00000385090

Symbol
  • CARD12
  • CLAN
  • CLAN1
  • IPAF
  • CLAN
  • IPAF
  • AIFEC
  • CLAN1
  • CLANA
  • CLANB
  • CLANC
  • CLAND
  • FCAS4
  • CARD12
  • CLR2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.97
tissue sample
0.77
protein domain
0.58
PubMedID
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 485.88   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 485.88   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0