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Tbio
NLGN4X
Neuroligin-4, X-linked

Protein Summary
Description
Putative neuronal cell surface protein involved in cell-cell-interactions. This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275857
  • ENSP00000275857
  • ENSG00000146938
  • ENST00000381092
  • ENSP00000370482
  • ENST00000381093
  • ENSP00000370483
  • ENST00000381095
  • ENSP00000370485
  • ENST00000538097
  • ENSP00000439203

Symbol
  • KIAA1260
  • NLGN4
  • HLNX
  • HNL4X
  • NLGN4
  • ASPGX2
  • AUTSX2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.66
microRNA
0.63
tissue sample
0.63
cellular component
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.42   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.42   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0