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Tbio
NLGN2
Neuroligin-2

Protein Summary
Description
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302926
  • ENSP00000305288
  • ENSG00000169992
  • ENST00000575301
  • ENSP00000461168
  • ENST00000639647
  • ENSP00000492323
  • ENSG00000283859
  • ENST00000640620
  • ENSP00000492198

Symbol
  • KIAA1366
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
biological process
0.86
protein domain
0.73
tissue sample
0.66
tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.83   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.83   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.923
Data Source:  BioPlex,STRINGDB
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.999825688
p_ni:  0.000174308
p_wrong:  4e-9
Data Source:  BioPlex
B3GAT3
Tbio
Family:  Enzyme
Novelty:  0.0289834
p_int:  0.999354513
p_ni:  0.000645465
p_wrong:  2.2e-8
Score:  0.225
Data Source:  BioPlex,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999002095
p_ni:  0.000997902
p_wrong:  3e-9
Data Source:  BioPlex
FAM19A2
Tbio
Novelty:  0.28999346
p_int:  0.994597297
p_ni:  0.005396497
p_wrong:  0.000006206
Data Source:  BioPlex
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.989389779
p_ni:  0.010434664
p_wrong:  0.000175557
Data Source:  BioPlex
TTC5
Tbio
Novelty:  0.12127698
p_int:  0.989387465
p_ni:  0.001993133
p_wrong:  0.008619403
Score:  0.179
Data Source:  BioPlex,STRINGDB
LYZL2
Tdark
Family:  Enzyme
Novelty:  0.50542161
p_int:  0.983874668
p_ni:  0.016116623
p_wrong:  0.000008709
Data Source:  BioPlex
CRISP2
Tbio
Novelty:  0.01862113
p_int:  0.974050052
p_ni:  0.025941386
p_wrong:  0.000008562
Score:  0.232
Data Source:  BioPlex,STRINGDB
MAN1A1
Tbio
Family:  Enzyme
Novelty:  0.00645679
p_int:  0.971600928
p_ni:  0.028387641
p_wrong:  0.000011431
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (47)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (62)
Items per page:
1 – 5 of 62
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
11
12
99.5
testosterone measurement
2
11
12
99.5
serum non-albumin protein measurement
1
4
4
93.2
serum non-albumin protein measurement
1
4
4
93.2
alkaline phosphatase measurement
1
1
1
86.7
Items per page:
1 – 5 of 62
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
12
99.5
testosterone measurement
12
99.5
serum non-albumin protein measurement
4
93.2
serum non-albumin protein measurement
4
93.2
alkaline phosphatase measurement
1
86.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuroligin 2
VGNC:9476
468441
Mouse
MGI:2681835
216856
Rat
RGD:621118
117096
Dog
neuroligin 2
VGNC:43839
479482
Horse
neuroligin 2
VGNC:20760
100072981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuroligin 2
Mouse
Rat
Dog
neuroligin 2
Horse
neuroligin 2
Publication Statistics
PubMed Score 65.83
PubMed score by year
PubTator Score 34.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title