Tbio NLE1 Notchless protein homolog 1

Protein Summary

Description

Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival (By similarity).

Uniprot Accession IDs

• Q9NVX2
• O60868
• Q59GJ8
• Q9BU54

Gene Name

• NLE1

Ensembl ID

• ENST00000442241
• ENSP00000413572
• ENSG00000073536
• ENST00000586869
• ENSP00000466588

Symbol

• NLE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
tissue	0.65
biological process	0.64
cellular component	0.64
histone modification site profile	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.49   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 205   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.49   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0