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Tbio
NKX6-1
Homeobox protein Nkx-6.1

Protein Summary
Description
Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (By similarity). Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity). In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295886
  • ENSP00000295886
  • ENSG00000163623

Symbol
  • NKX6A
  • NKX6A
  • NKX6.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.81
cell type or tissue
0.78
protein domain
0.73
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.05   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 139.05   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
ONECUT1
Tbio
Family:  TF
Novelty:  0.0086548
Score:  0.969
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.941
Data Source:  STRINGDB
PDX1
Tbio
Family:  TF
Novelty:  0.00232117
Score:  0.933
Data Source:  STRINGDB
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
Score:  0.928
Data Source:  STRINGDB
ISL1
Tbio
Family:  TF
Novelty:  0.00169431
Score:  0.846
Data Source:  STRINGDB
OLIG2
Tbio
Family:  TF
Novelty:  0.0015221
Score:  0.81
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.81
Data Source:  STRINGDB
PTF1A
Tbio
Family:  TF
Novelty:  0.00593299
Score:  0.804
Data Source:  STRINGDB
SLC2A2
Tchem
Family:  Transporter
Novelty:  0.00103579
Score:  0.797
Data Source:  STRINGDB
TLE3
Tbio
Novelty:  0.02641884
Score:  0.779
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in beta cells
Reactome
Regulation of gene expression in early pancreatic precursor cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in beta cells
Regulation of gene expression in early pancreatic precursor cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
3
2
2
1.2
78.2
Drugs used in diabetes use measurement
2
1
2
7.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1.2
78.2
Drugs used in diabetes use measurement
2
7.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NK6 homeobox 1
VGNC:13052
471184
Macaque
NK6 homeobox 1
706844
Mouse
MGI:1206039
18096
Rat
RGD:69318
65193
Dog
NK6 homeobox 1
VGNC:54334
487838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NK6 homeobox 1
Macaque
NK6 homeobox 1
Mouse
Rat
Dog
NK6 homeobox 1
Publication Statistics
PubMed Score 139.05
PubMed score by year
PubTator Score 61.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title