NKX3-1
Homeobox protein Nkx-3.1
Protein Summary
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
- ENST00000380871
- ENSP00000370253
- ENSG00000167034
- ENST00000523261
- ENSP00000429729
- NKX3.1
- NKX3A
- NKX3
- BAPX2
- NKX3A
- NKX3.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
molecular function | 1 | ||
histone modification site profile | 0.78 | ||
virus perturbation | 0.76 | ||
microRNA | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 247.18 (req: < 5)
Gene RIFs: 95 (req: <= 3)
Antibodies: 626 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 247.18 (req: >= 5)
Gene RIFs: 95 (req: > 3)
Antibodies: 626 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 59
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0