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Tbio
NKX2-3
Homeobox protein Nkx-2.3

Protein Summary
Description
Transcription factor. This gene encodes a homeodomain-containing transcription factor. The encoded protein is a member of the NKX family of homeodomain transcription factors. Studies of similar proteins in mouse and rat have indicated a potential role in cellular differentiation.[provided by RefSeq, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344586
  • ENSP00000342828
  • ENSG00000119919

Symbol
  • NKX23
  • NKX2C
  • CSX3
  • NK2.3
  • NKX2C
  • NKX2.3
  • NKX4-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
phenotype
0.82
gene perturbation
0.62
PubMedID
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.14   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.14   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
TBX5
Tbio
Family:  TF
Novelty:  0.00272208
Score:  0.855
Data Source:  STRINGDB
MADCAM1
Tbio
Novelty:  0.00325843
Score:  0.749
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.707
Data Source:  STRINGDB
GNA12
Tbio
Novelty:  0.06310884
Score:  0.635
Data Source:  STRINGDB
KAT7
Tbio
Family:  TF; Epigenetic
Novelty:  0.01783137
Score:  0.629
Data Source:  STRINGDB
TBX6
Tbio
Family:  TF
Novelty:  0.01060902
Score:  0.607
Data Source:  STRINGDB
HAND2
Tbio
Family:  TF
Novelty:  0.00478924
Score:  0.602
Data Source:  STRINGDB
SPNS2
Tbio
Novelty:  0.0271697
Score:  0.594
Data Source:  STRINGDB
MEF2C
Tbio
Family:  TF
Novelty:  0.00232724
Score:  0.587
Data Source:  STRINGDB
INSYN2
Tdark
Novelty:  2.55244594
Score:  0.586
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
1
1.2
99
4
3
1
1.2
97.6
monocyte count
6
4
6
94.8
7
4
0
1.1
93.9
mean corpuscular volume
3
4
4
85.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
99
1
1.2
97.6
monocyte count
6
94.8
0
1.1
93.9
mean corpuscular volume
4
85.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NK2 homeobox 3
VGNC:4963
743725
Macaque
NK2 homeobox 3
708540
Mouse
MGI:97348
18089
Rat
RGD:1308521
309389
Dog
NK2 homeobox 3
VGNC:53002
100684882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NK2 homeobox 3
Macaque
NK2 homeobox 3
Mouse
Rat
Dog
NK2 homeobox 3
Publication Statistics
PubMed Score 52.14
PubMed score by year
PubTator Score 21.43
PubTator score by year
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Related Publications
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PMID
Year
Title