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Tbio
NKX2-2
Homeobox protein Nkx-2.2

Protein Summary
Description
Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377142
  • ENSP00000366347
  • ENSG00000125820

Symbol
  • NKX2.2
  • NKX2B
  • NKX2B
  • NKX2.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
molecular function
0.73
virus perturbation
0.72
gene perturbation
0.68
PubMedID
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.07   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 815   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.07   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 815   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (158)
NEUROG3
Tbio
Family:  TF
Novelty:  0.00341077
Score:  0.983
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.974
Data Source:  STRINGDB
OLIG2
Tbio
Family:  TF
Novelty:  0.0015221
Score:  0.954
Data Source:  STRINGDB
PAX6
Tbio
Family:  TF
Novelty:  0.00064695
Score:  0.928
Data Source:  STRINGDB
FOXA2
Tbio
Family:  TF
Novelty:  0.00244521
Score:  0.911
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.867
Data Source:  STRINGDB
PAX4
Tbio
Family:  TF
Novelty:  0.00697085
Score:  0.835
Data Source:  STRINGDB
ISL1
Tbio
Family:  TF
Novelty:  0.00169431
Score:  0.833
Data Source:  STRINGDB
TLE3
Tbio
Novelty:  0.02641884
Score:  0.777
Data Source:  STRINGDB
OLIG1
Tbio
Family:  TF
Novelty:  0.01006324
Score:  0.776
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of beta-cell development
Reactome
Regulation of gene expression in beta cells
Reactome
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of beta-cell development
Regulation of gene expression in beta cells
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.8
17.1
IGF-1 measurement
1
1
1
15.6
balding measurement
1
1
1
7.4
BMI-adjusted hip circumference
1
1
1
3
1
1
0
1.1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.8
17.1
IGF-1 measurement
1
15.6
balding measurement
1
7.4
BMI-adjusted hip circumference
1
3
0
1.1
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NK2 homeobox 2
VGNC:6214
469894
Mouse
MGI:97347
18088
Rat
RGD:1308443
366214
Dog
NK2 homeobox 2
VGNC:43833
485744
Horse
NK2 homeobox 2
VGNC:20754
100050029
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NK2 homeobox 2
Mouse
Rat
Dog
NK2 homeobox 2
Horse
NK2 homeobox 2
Publication Statistics
PubMed Score 153.07
PubMed score by year
PubTator Score 67.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title