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Tbio
NKX2-1
Homeobox protein Nkx-2.1

Protein Summary
Description
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354822
  • ENSP00000346879
  • ENSG00000136352
  • ENST00000498187
  • ENSP00000429607
  • ENST00000518149
  • ENSP00000428341
  • ENST00000522719
  • ENSP00000429519

Symbol
  • NKX2A
  • TITF1
  • TTF1
  • BCH
  • BHC
  • NK-2
  • TEBP
  • TTF1
  • NKX2A
  • NMTC1
  • T/EBP
  • TITF1
  • TTF-1
  • NKX2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.77
phenotype
0.68
biological term
0.67
molecular function
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1724.55   (req: < 5)
Gene RIFs: 285   (req: <= 3)
Antibodies: 958   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1724.55   (req: >= 5)
Gene RIFs: 285   (req: > 3)
Antibodies: 958   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0