NKIRAS2
NF-kappa-B inhibitor-interacting Ras-like protein 2
Protein Summary
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
- ENST00000307641
- ENSP00000303580
- ENSG00000168256
- ENST00000393880
- ENSP00000377458
- ENST00000393881
- ENSP00000377459
- ENST00000393885
- ENSP00000377463
- ENST00000449471
- ENSP00000401976
- ENST00000479407
- ENSP00000465633
- KBRAS2
- KBRAS2
- kappaB-Ras2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.93 | ||
molecular function | 0.9 | ||
transcription factor binding site profile | 0.79 | ||
transcription factor | 0.75 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.27 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 191 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.27 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 191 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0