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Tbio
NKD2
Protein naked cuticle homolog 2

Protein Summary
Description
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells. This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274150
  • ENSP00000274150
  • ENSG00000145506
  • ENST00000296849
  • ENSP00000296849
  • ENST00000610777
  • ENSP00000482896
  • ENSG00000276920
  • ENST00000616539
  • ENSP00000479003

Symbol
  • Naked2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.78
PubMedID
0.64
tissue sample
0.61
tissue
0.54
transcription factor binding site profile
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.28   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.28   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.989293855
p_ni:  0.010706145
Score:  0.204
Data Source:  BioPlex,STRINGDB
UBE2D2
Tbio
Novelty:  0.00603877
p_int:  0.974249295
p_ni:  0.015781272
p_wrong:  0.009969433
Score:  0.189
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.945434463
p_ni:  0.054565537
Data Source:  BioPlex
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.886810844
p_ni:  0.113189156
Score:  0.219
Data Source:  BioPlex,STRINGDB
YWHAB
Tchem
Novelty:  0.00614093
p_int:  0.880907772
p_ni:  0.119092228
Score:  0.167
Data Source:  BioPlex,STRINGDB
ARMT1
Tbio
Family:  Enzyme
Novelty:  0.19632869
p_int:  0.877339193
p_ni:  0.084031967
p_wrong:  0.038628839
Score:  0.234
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.86100988
p_ni:  0.138990063
p_wrong:  5.7e-8
Data Source:  BioPlex
PMVK
Tchem
Family:  Enzyme
Novelty:  0.00468598
p_int:  0.786113257
p_ni:  0.213244522
p_wrong:  0.000642221
Score:  0.163
Data Source:  BioPlex,STRINGDB
DVL1
Tchem
Novelty:  0.00356876
Score:  0.992
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.952
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
21
31
99.9
red blood cell distribution width
6
21
31
99.9
mean corpuscular hemoglobin concentration
5
5
6
96.8
mean corpuscular hemoglobin concentration
5
5
6
96.8
mean corpuscular volume
3
3
3
92.2
Items per page:
1 – 5 of 32
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
31
99.9
red blood cell distribution width
31
99.9
mean corpuscular hemoglobin concentration
6
96.8
mean corpuscular hemoglobin concentration
6
96.8
mean corpuscular volume
3
92.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
naked cuticle homolog 2
VGNC:13554
461692
Macaque
naked cuticle homolog 2
709500
Mouse
MGI:1919543
72293
Rat
RGD:1311459
308068
Dog
naked cuticle homolog 2
VGNC:54105
488070
Species
Name
OMA
EggNOG
Inparanoid
Chimp
naked cuticle homolog 2
Macaque
naked cuticle homolog 2
Mouse
Rat
Dog
naked cuticle homolog 2
Publication Statistics
PubMed Score 29.28
PubMed score by year
PubTator Score 18.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title