Tbio NKD1 Protein naked cuticle homolog 1

Protein Summary

Description

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]

Uniprot Accession IDs

• Q969G9
• B2RC39
• Q8WZ08
• Naked-1

Gene Name

• NKD1

Ensembl ID

• ENST00000268459
• ENSP00000268459
• ENSG00000140807

Symbol

• NKD
• Naked1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.67
PubMedID	0.63
histone modification site profile	0.6
biological process	0.59
tissue sample	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.5   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 139   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.5   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0