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Tdark
NKAIN3
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3

Protein Summary
Description
NKAIN3 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000523211
  • ENSP00000429073
  • ENSG00000185942

Symbol
  • FAM77D
  • FAM77D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
trait
0.86
microRNA
0.84
phenotype
0.69
histone modification site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 7   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.08   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 7   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
SPATA31D1
Tdark
Novelty:  1.43869343
Score:  0.743
Data Source:  STRINGDB
BUD13
Tbio
Novelty:  0.05228416
Score:  0.66
Data Source:  STRINGDB
FSTL5
Tbio
Novelty:  0.09979909
Score:  0.635
Data Source:  STRINGDB
PTPN14
Tbio
Family:  Enzyme
Novelty:  0.01333024
Score:  0.595
Data Source:  STRINGDB
TRAM1L1
Tdark
Novelty:  0.36358498
Score:  0.592
Data Source:  STRINGDB
ZNF738
Tdark
Novelty:  6.56360276
Score:  0.586
Data Source:  STRINGDB
KCTD16
Tbio
Novelty:  0.09898256
Score:  0.584
Data Source:  STRINGDB
ISM1
Tbio
Novelty:  0.03082946
Score:  0.567
Data Source:  STRINGDB
HES4
Tbio
Family:  TF
Novelty:  0.05290912
Score:  0.547
Data Source:  STRINGDB
CADPS2
Tbio
Novelty:  0.05201813
Score:  0.526
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
2
2
81.6
calcium measurement
2
1
2
53.8
age at onset
1
1
0
5.8
36.2
Alzheimer disease
1
1
0
5.8
36.2
reading and spelling ability
1
1
1
35.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
81.6
calcium measurement
2
53.8
age at onset
0
5.8
36.2
Alzheimer disease
0
5.8
36.2
reading and spelling ability
1
35.5
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2444830
269513
Rat
RGD:1591051
689576
Opossum
sodium/potassium transporting ATPase interacting 3 [Source:HGNC Symbol;Acc:HGNC:26829]
Xenopus
Sodium/potassium transporting ATPase interacting 3
XB-GENE-5816251
779682
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Opossum
sodium/potassium transporting ATPase interacting 3 [Source:HGNC Symbol;Acc:HGNC:26829]
Xenopus
Sodium/potassium transporting ATPase interacting 3
Publication Statistics
PubMed Score 1.08
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title